Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CPT > 6. Antiplatelet And Fibrinolytic Drugs > Flashcards

6. Antiplatelet And Fibrinolytic Drugs Flashcards

You may prefer our related Brainscape-certified flashcards:
NASM ® CPT flashcards
1
Q

Which drugs are used in platelet rich ‘white’ arterial thrombi?

A

Antiplatelet and fibrinolytic drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which drugs are used in lower platelet content, ‘red’ venous thrombi?

A

Parenteral anticoagulants and oral anticoagulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Name a cyclo-oxygenase inhibitor

A

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the action of cyclo-oxygenate inhibitors?

A

Inhibits COX-1 mediated production of TXA2 and reduces platelet aggregation - irreversible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the adverse affects of aspirin?

A

GI irritation, GI bleeding, haemorrhage, hypersensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the contraindications of aspirin?

A 
Reye’s syndrome - avoid <16 years
Hypersensitivity 
3rd trimester (premature closure of ductus arteriosus)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the important drug interactions with aspirin?

A

Other antiplatelet and anticoagulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are some indications of aspirin?

A

Antithrombotic
Atrial fibrillation
Secondary retention of stroke and TIA
Secondary prevention of acute coronary syndromes
Often co prescribed with other antiplatelet drugs
NSTEMI/STEMI
Acute ischaemic stroke

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is required in long term use of aspirin?

A

Gastric protection - proton pump inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name some ADP receptor antagonists

A

Clopidogrel
Prasugrel
Ticagrelor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the action of ADP receptor antagonists?

A

Inhibit dining of ADP to P2Y12 receptor, therefore inhibiting activation of GPIIb/IIIa receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which ADP receptor antagonists have slow onset of action and which have fast?

A

Clopidogrel has slow onset of action without a loading dose

Ticagrelor and prasugrel have a more rapid onset of action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the adverse effects of ADP receptor antagonists?

A

Bleeding
GI upset - dyspepsia, diarrhoea
Rarely thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the contraindications of ADP receptor antagonists?

A

Caution in high bleed risk patients with renal and hepatic impairment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the important drug reactions wit ADP receptor antagonists?

A

Clopidogrel requires CYPs for activation therefore:
- CYP inhibitors (omeprazole, ciprofloxacin, erythromycin, some SSRIs
Ticagrelor can interact with CYP inhibitors and inducers
Caution when co prescribed with other antiplatelet and anticoagulant agents or NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When would clopidogrel need to be stopped?

A

7 days prior to surgery

17
Q

When are ADP receptor antagonists used?

A

Clopidogrel as mono therapy when aspirin is contraindicated
NSTEMI patients up to 3 months
STEMI patients up to 4 weeks
Ischaemic stroke and TIA long term secondary prevention

18
Q

Name a phosphodiesterase inhibitor

A

Dipyridamole

19
Q

What is the action of phosphodiesterase inhibitors?

A

Dipyridamole inhibits cellular reuptake of adenosine, this increases [adenosine], which inhibits platelet aggregation via adenosine receptors
Also prevents cAMP degradation which inhibits expression of GPIIb/IIIa

20
Q

What are the adverse effects of phosphodiesterase inhibitors?

A

V and D

Dizziness

21
Q

What are the important drug reactions with phosphodiesterase inhibitors?

A

Antiplatelets and anticoagulants, adenosine

22
Q

When are phosphodiesterase inhibitors used?

A

Antiplatelet
Secondary prevention of ischaemic stroke and TIAs
Adjunct for prophylaxis of thromboembolism following valve replacement
Stroke

23
Q

Give an example of glycoprotein IIb/IIIa inhibitors

A

Abciximab

24
Q

What is the action of glycoproteins IIb/IIIa inhibitors?

A

Blocks binding of fibrinogen and vWF

Target final common pathway leading to more complete platelet aggregation

25
Q

What are the adverse effects of glycoprotein IIb/IIIa inhibitors?

A

Bleeding

26
Q

What are the important drug interactions with abciximab?

A

Caution with other antiplatelet and anticoagulant agents

27
Q

When is abciximab used?

A

Specialist use in high risk percutaneous transluminal coronary angioplasty patients with other drugs

28
Q

How do fibrinolytic agents work?

A

Dissolve the fibrin mesh work of thrombus

29
Q

What are the adverse effects of fibrinolytic agents?

A

Bleeding

30
Q

What are the important drug reactions with fibrinolytic agents?

A

Antiplatelets and anticoagulants

31
Q

What are some fibrinolytic agents?

A

Streptokinase
Alteplase
Tranexamic acid - stops bleeding

32
Q

Why can streptokinase not be used more than once?

A

Antibodies develop

CPT (30 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions