8/9/13

Question 1

C1 Esterase Deficency

Answer 1

-Causes hereditery angioedema. ACE inhibitors should not be used in patients with hereditery angioedema because it can exacerbate the vasodilation that results in edema.

Question 2

Infectous Mononucleosis

Answer 2

• Caused by the epstien bar virus
• Identified by cervical lymphadenopathy, fever, splenomegaly and malaise
• Epstein Bar virus infects mature B cells throught CD21, complement receptor.
• The major immune response generated would be CD8 cytotoxic.

Question 3

CD21

Answer 3

-Marker for mature B cells and follicular dendritic Cells

Question 4

CD14

Answer 4

-Receptor for LPS that is present on monocytes and macrophages and leads to their activation.

Question 5

Polymyositis

Answer 5

• Disease caused by an overaction of the immune system possibly due to viral infection that results in the activation of CD4 cells, increased MHC 1 expression and eventual activation and inflilatration of CD8 cells into muscle tissue.
• Signs and symptoms begin with bilateral proximal muscle weakness and fatigue. Elevated creatine kinase and anti-Jo antibodies is also seen.

Question 6

Polymyalgia Rheumatica

Answer 6

• Presents with proximal weakness similiar to polymyositis and bilateral stiffness.
• Associated with temporal arteritis and an elevated ESR.

Question 7

Lambert-Eaton Syndrome

Answer 7

• Paraneoplastic syndrome
• Muscle weakness that improves with exercise
• Autoantibodies to Ca channels are the cause.

Question 8

Myasthenia Gravis

Answer 8

• Muscle weakness that gets worse with exercise and extraocular involvment (ptosis) are the signs.
• Antibodies directed to the Ach Receptor are the cause.

Question 9

Campylobacter

Answer 9

• Major cause of gastroenteritis
• Can be transmitted from dogs or other domestic animals to humans.
• The most common cause of post infection Guillen Bare

Question 10

Complement deficency in MAC

Answer 10

• Causes repeated infections with Nisseria species organisms

Question 11

Sickle Cell patient with aplastic crisis

Answer 11

-Infection with Parvovirus B19, a non enveloped single stranded DNA virus

Question 12

Hematopoetic Depression in “normal” patients

Answer 12

-Epstien Bar virus, that infects B cells through CD 21 can cause a hematopoetic depression and anemia. Not as severe as aplastic crisks in Parvovirus B19.

Question 13

Injection Skin Reaction Hypersensitivities

Answer 13

-Any injection skin reaction like TB test or other test or contact dermatitis are mediated by T cells, that call in macrophages by secretion of IFN-gamma to the site.