8/5/13

Question 1

Chronic Granulomatous Disease

Answer 1

-Mutation in NADPH peroxidase. X linked. Testing with Nitroblue Tetrazolium does not turn blue
Susceptible to catalase positive like S Aureus

Question 2

SCID

Answer 2

-Adenosine Deaminase Deficency. Absent T and B lymphocytes and agammaglobunemia

Question 3

Pyruvate Kinase

Answer 3

• Hemolytic Anemia

- G6PD also causes hemolytic anemia and is more common. Favism, heinz bodies.

Question 4

Cyt C Oxidase Deficency

Answer 4

• Mitochondiral dysfunction

- Hypotonia, weakness, encephalopathy

Question 5

Hyperacute Rejection

Answer 5

• Occurs because of preformed Ab and is caused by thrombosis in vessels of graft, complement activation, and infiltration of Neutrophils
• Within 10 hrs

Question 6

Acute Rejection

Answer 6

-Dense Cellular Infiltrate, Longer than 1 day but follows immune restoration

Question 7

Chronic Graft Rejection

Answer 7

• Minimal to lymphocyte infiltration
• Fibrosis is most notable
• More time has passed, 1yr+ often more.

Question 8

HSV-1

Answer 8

Young patient with gingivostomatitis

• Cold Sores
• HSV-1 is a DS DNA virus.