8/8/13

Question 1

Legionella pneumoniae

Answer 1

• Pneumonia with high fever dehydration and diharrea. Also hyponatremia
• Sputum sample does not show bacteria because of difficulty to stain
• Urine test is diagnsitc

Question 2

Mycobacterium pneumoniae

Answer 2

• Pneumoniae with AFB that are difficult to gram stai. Often infects young adults

Question 3

Mycobacterium kanasii

Answer 3

• Appears somewhat similiar to MTB
• Difficult to stain and AFB
• Lives in marine environment and often contaminates water. Non transmissable from human to human

Question 4

Kleibesella pneumoniae

Answer 4

-Pneumonia with a gram negative rod

Question 5

Coccoides immitis

Answer 5

-Fungus that can cause disseminated infection in immunocompromised, but generally does not cause disease in healthy host

Question 6

Post Streptococcal Glomerulonepphritis

Answer 6

• Kidney damage and edema following streptococcal infection (Impetgigo, folliculutis, etc)
• Type 3 hypersensitivity, lumpy bumpy deposition of Ab that are cross reactive to self on glomerular membrane.

Question 7

Hepatitis A

Answer 7

• Hepatitis A is a self limiting disease that does not have a chronic disease state or a carrier state.
• The disease often presents anicterically (without jaundice) in children

Question 8

Hemolytic Disease of the Newborn

Answer 8

• Type 2 hypersensitivity
• Mothers with type O blood often make antibodies to both types A and B blood. These antibodies are IgG and can cause disease on the first pregnancy (different than Rh)
• Mothers type A or B make IgM Ab which cannot cross the placenta and do not cause hemolytic disease of the newborn in this case. Rh still can.
• Disease from Rh antigen is more severe than disease from AB antigen.
• Can be screened by coombs test, serum causing agglutination of RBCs

Question 9

7 y/o Lack of Thymus with very low serum gammaglobulin with recurrent infections

Answer 9

• SCID is the correct answer. Shows as a lack of B and T cells with nearly absent Ig. Many causes, X linked, bare lymphocyte, Omen, Adenosine deaminase.
• DiGeiorge is not correct because it is more rare and has a less severe case of immunodeficency with diminshed levels of B and T Cells and decreased Ig. Also there are no other findings charaacteristic (facial anomilies, tetrology of falot, etc)
• X linked agammaglobunemia -lack btk and inability for B cells to mature
• Wiskott-Aldrich:X linked, eczema, thrombocytopenia, immunodeficency, problem with immunological synapse