8/28/13

Question 1

A blister is a type of injury that can be classified at what outcome in acute inflammation

Answer 1

resolution

Question 2

what causes fibrinous inflammation

Answer 2

severe injury leads to increased exudate which includes fibrinogen and plasma proteins–> Fibrinogen organizes into fibrin mass–> if macrophages don’t remove these masses will organize with the aid of fibroblasts and for a scar

Question 3

What is the difference between fibrinous and fibrinopurulent imflammation?

Answer 3

Fibrinopurulent has the presence of neutrophils

Question 4

Large amounts of neutrophils, edema and necrotic cells are typical of this type of inflammation

Answer 4

suppurative inflammation

Question 5

Abscesses are focal sites of what?

Answer 5

suppurative inflammation around an invading organism

Question 6

Erosion or necrosis of an area of surface epithelium with associated acute and chronic inflammation beneath the epithelial surface is characteristic of

Answer 6

Ulcer (neutrophil in eroded pit)

Question 7

Organism that cause suppurative inflammation and pus formation are called

Answer 7

pyogenic

Question 8

Angiogenesis and fibrosis indicates

Answer 8

cell repair

Question 9

What two things are going on during chronic inflammation?

Answer 9

Cell repair and cellular damage

Question 10

What is the structure of a granuloma

Answer 10

Epithelioid macrophages surrounded by lymphocytes

Question 11

Which cytokines mediate the acute phase reaction?

Answer 11

IL-1, IL6, TNF

Question 12

Which cytokines in the acute phase reaction stimulate a fever response?

Answer 12

IL-1 and TNF

Question 13

Which cytokines in the acute phase reaction stimulates an increase in SED rates by increasing hepatic synthesis of plasma protein, fibrinogens aggregates RBC

Answer 13

IL-6

Question 14

What are the tumor suppressors which have checkpoints at G1 and G2

Answer 14

p53 induces transcription of p21 which is a CDK inhibitor

Question 15

EGF and FGF work through this type of receptor

Answer 15

receptor with intrinsic kinase activity

Question 16

Chemokines work through this type of receptor

Answer 16

G-protein receptor

Question 17

Cytokines work through this type of receptor

Answer 17

Receptor without intrinsic enzyme activity

Question 18

What type of collagen makes up the basement membrane?

Answer 18

Type IV

Question 19

Fibrillar, non-fibrillar, proteoglycan, glycoprotein

Answer 19

Interstitial matrix

Question 20

Which types of collagen form fibrils by crosslinking

Answer 20

Type I,II,III, V

Question 21

How are elastin fibers organized?

Answer 21

Elastin protein core surrounded by fibrillin glycoprotein mesh (defects can lead to Marfan syndrome)

Question 22

These types of molecules can bind and store growth factors in the ECM

Answer 22

heparan sulfate ,hyaluronan and syndecan (bound to cytoskeletal components of the cell)

Question 23

Two types of adhesive glycoproteins in the ECM

Answer 23

Fibronectin and laminin

Question 24

Fibroblast and endothelial cell proliferation signals the formation of this structure after tissue injury

Answer 24

granulation tissue

Question 25

These two growth factors are important during angiogenesis

Answer 25

VEGF, FGF (FGF2, bFGF)

Question 26

Which growth factors are responsible for recruiting and proliferation of fibroblasts during scar formation?

Answer 26

PDGE, TGF beta, FGF-2

Question 27

Which molecules are responsible for promoting the secretion of collagen by fibroblasts during scar formation?

Answer 27

IL-1, TNF

Question 28

What enzymes are used to digest collagen during scare remodeling?

Answer 28

Metalloproteinases, stromelysins

Question 29

TIMPS protect against what?

Answer 29

Metalloproteinases