8/28/13 Flashcards
A blister is a type of injury that can be classified at what outcome in acute inflammation
resolution
what causes fibrinous inflammation
severe injury leads to increased exudate which includes fibrinogen and plasma proteins–> Fibrinogen organizes into fibrin mass–> if macrophages don’t remove these masses will organize with the aid of fibroblasts and for a scar
What is the difference between fibrinous and fibrinopurulent imflammation?
Fibrinopurulent has the presence of neutrophils
Large amounts of neutrophils, edema and necrotic cells are typical of this type of inflammation
suppurative inflammation
Abscesses are focal sites of what?
suppurative inflammation around an invading organism
Erosion or necrosis of an area of surface epithelium with associated acute and chronic inflammation beneath the epithelial surface is characteristic of
Ulcer (neutrophil in eroded pit)
Organism that cause suppurative inflammation and pus formation are called
pyogenic
Angiogenesis and fibrosis indicates
cell repair
What two things are going on during chronic inflammation?
Cell repair and cellular damage
What is the structure of a granuloma
Epithelioid macrophages surrounded by lymphocytes
Which cytokines mediate the acute phase reaction?
IL-1, IL6, TNF
Which cytokines in the acute phase reaction stimulate a fever response?
IL-1 and TNF
Which cytokines in the acute phase reaction stimulates an increase in SED rates by increasing hepatic synthesis of plasma protein, fibrinogens aggregates RBC
IL-6
What are the tumor suppressors which have checkpoints at G1 and G2
p53 induces transcription of p21 which is a CDK inhibitor
EGF and FGF work through this type of receptor
receptor with intrinsic kinase activity
Chemokines work through this type of receptor
G-protein receptor
Cytokines work through this type of receptor
Receptor without intrinsic enzyme activity
What type of collagen makes up the basement membrane?
Type IV
Fibrillar, non-fibrillar, proteoglycan, glycoprotein
Interstitial matrix
Which types of collagen form fibrils by crosslinking
Type I,II,III, V
How are elastin fibers organized?
Elastin protein core surrounded by fibrillin glycoprotein mesh (defects can lead to Marfan syndrome)
These types of molecules can bind and store growth factors in the ECM
heparan sulfate ,hyaluronan and syndecan (bound to cytoskeletal components of the cell)
Two types of adhesive glycoproteins in the ECM
Fibronectin and laminin
Fibroblast and endothelial cell proliferation signals the formation of this structure after tissue injury
granulation tissue
These two growth factors are important during angiogenesis
VEGF, FGF (FGF2, bFGF)
Which growth factors are responsible for recruiting and proliferation of fibroblasts during scar formation?
PDGE, TGF beta, FGF-2
Which molecules are responsible for promoting the secretion of collagen by fibroblasts during scar formation?
IL-1, TNF
What enzymes are used to digest collagen during scare remodeling?
Metalloproteinases, stromelysins
TIMPS protect against what?
Metalloproteinases
