8/22/13

Question 1

5 most common signaling mechanisms

Answer 1

GPCR, transcription factors, ligand gated channels, tyrosine kinase, ligand gated transmembrane enzymes

Question 2

acetylcholine effect on muscarinic (slow) and nictonic (fast) receptors is an example of

Answer 2

Convergent evolution

Question 3

cellular target and effect of Gs protein

Answer 3

adenyly cyclase, increases cAMP

Question 4

Cellular target and effect of Gi protein

Answer 4

adenyly cyclase, deacreases cAMP/ K+ channels, increases inracellular concentration of K+ (hyperpolarization)

Question 5

Cellular target and effect of Gq protein

Answer 5

phospholipase C, PI and DAG

Question 6

what is a quantal dose response curve?

Answer 6

compares the percentage of individual responding to the dosage concentration

Question 7

4 types of hypersensitivity and what mediate them

Answer 7

Type 1- Anaphylactic reaction–> IgE mediated, mast cells
Type 2- cytolytic reaction–> IgG, IgM mediated, complement
Type 3- Arthrus reaction–> IgG mediated, serum sickness
Type 4- Delayed Hypersensitivity reactions–> T-lymphocyte mediated

Question 8

Which classification of drugs are physicians not allowed to prescribe?

Answer 8

Schedule I

Question 9

Classification of fetal risk due to drugs that are ideal but rare

Answer 9

Category A

Question 10

Classification of fetal risk due to drugs that are a real risk, use only if no choice

Answer 10

Category D

Question 11

Classification of fetal risk due to drugs that have some risk in animals but little human data

Answer 11

Category C

Question 12

Classification of fetal risk due to drugs that have little evidence for risk and are often preferred drugs

Answer 12

Category B

Question 13

Classification of fetal risk due to drugs that are bad

Answer 13

Category X