8/20/13

Question 1

Too little drug, no effect

Answer 1

subeffective dose

Question 2

Threshold effect and threshold dose

Answer 2

minimally effective dose

Question 3

Graded response, increasing dose increases intensity of effect

Answer 3

dose dependent

Question 4

Ceiling effect

Answer 4

maximally effective dose

Question 5

Related to the size of the dose necessary to provide a certain effect, determined by the affinity of the receptor for the drug

Answer 5

Potency

Question 6

Often used to measure drug potency

Answer 6

ED50

Question 7

Related to the maximal effect obtained by the drug

Answer 7

Efficacy

Question 8

Drug that binds to a receptor to produce a biologic response

Answer 8

Agonist

Question 9

Drug that binds to a receptor and prevent the interaction of an agonist with the receptor

Answer 9

Antagonist

Question 10

The magnitude of a pharmacologic response elicited by a drug which reversibly combines with its receptor is proportional to ____

Answer 10

the number or fraction of receptors occupied by the drug

Question 11

Produces a ceiling effect that is not exceeded by other drugs

Answer 11

Full agonist

Question 12

Full agonist and partial agonist differ in ____ but may or may not differ in _____

Answer 12

Efficacy, potency

Question 13

Preference for inactive state

Answer 13

Inverse agonist

Question 14

Difference between Inverse agonist and competitive antagonist

Answer 14

inverse agonist take receptor BELOW basal activity while competitive antagonist takes it to basal activity

Question 15

Can potentiate effects of endogenous regulators

Answer 15

Allosteric activators

Question 16

Antagonist has ____ for the receptor, but low to zero____

Answer 16

Affinity, efficacy

Question 17

A competitive inhibitor will shift the dose-response curve to the

Answer 17

right

Question 18

Compounds that bind to or inactivate an agonist before it can bind to its receptor

Answer 18

chemical antagonists

Question 19

Noncompetitive antagonist always decreases the

Answer 19

maximal response (may or may not affect the potency of the agonist)

Question 20

Physiological antagonists

Answer 20

Noncompetitive, blocks consequences of agonist binding to receptor

Question 21

What can act like competitive antagonists at spare receptors?

Answer 21

Non-competitive antagonists

Question 22

Spare receptors _____ the concentration of agonist required for full effect

Answer 22

decreases

Question 23

Special class of proteins whose biological role is to receive signals from other cells or to sense the outside environment of cells

Answer 23

physiological receptors

Question 24

extracellular signals that use physiological receptors

Answer 24

neurotransmitters, endocrine hormones, paracrine hormones, autocoids

Question 25

single largest class of drug targets

Answer 25

physiological receptors