7.1 - Pain pt 1 Flashcards
pain is essential for..*2 warns of …*3
- maintenance 2. survival of an individual 1. danger of bodily harm 2. alerts to trauma / injury 3. signals - unhealthy conditions - inflam. tiss
IASP def - pain:
unplesants -sensory -emotional experience assoc w - actual - or potential tiss damage or described in terms of such damage (merskey 1986)
sensory receptors -funct
- info about enviro 2. detect spec. type of -info -or ext. cue via -spec sensory endings 3. receptors convert - physical energy int electrochemical activation of assoc neuron
one spec. receptor in the epidermis is for …
pain receptors
other receptors in the dermis are for
- heat 2. light tough 3. cold 4. hair mov 5. strong pressure
nociceptors: (latin - nocere = to injure)
receptors that respond selectively to -noxious - or potent. damaging stim.
describe - nociceptors
- periph free endings of -primary sensory neurons 2. cell bodies loc. - dorsal root - trigem ganglia 3. (unlike other somat.sens. recep. nocicep. are - poorly differentiated - lack the structures for filtering periph. stim.
nociceptors - firing - noxious stim - duration and freq of burst det. by..*2
do not fire spontaneously at rest when noxious stim. is of suffic. str. it - depolarises the nociceptor membrain duration and freq. of burst -determined by 1. duration 2. intensity of nox. stim
experiments in the 30s and 60s - determined pain was signalled by?
- A-Delta fibres (sm diam. thinly myelinated) 2. C-Fibres (sm diam. unmyelinated)
describe - a-delta fibres - c-fibres
- A-Delta fibres - well localised sensations of - sharp - prickling 2. C-Fibres - poorly localised - dull - diffuse - persistent
nociceptors - 3 kinds of stimuli ca activate
- mechanical _(squash facet joint) 2. thermal _(burn on stove) 3. chemical _(hot chill capsacin molecule)
nociceptors - densely populated in ..*8
- skin 2. mus 3. bone 4. joint capsules 5. viscera 6. blood vessels 7. meninges 8. peripheral nerve sheath
nociceptors - not found in ..*7
- articular cartilage 2. synovial memb. 3. lung parenchyma 4. visceral pleura 5. pericardium 6. brain 7. spinal cord tiss.
describe dorsal root ganglion -type neuron -nucl loc - funct - effects - reg
DRG cell = pseudo-unipolar all sens. neuron peripheral = nucl. in DRG funct = control centre (modulation and evaluation- first place msg come in) anything affecting DRG = has profound eff. on whole periphal nerve reg= sprouting of sensors (under the direction of DNA)
3 classifications of - stimuli
- exteroceptive (external enviro) 2. interoceptive (internal enviro) 3. proprioception (positioning - where the limbs are in space)
nociception 2 types?
- exteroceptive stimuli = sense picked up from out bod 2. interoceptive stimuli = sense picked up from in bod
diff btw radicular pain radiculopathy
radicular pain = radicular (aka spinal nerve) nerve pain radiculopathy = pathology of a radiular nerve (spinal nerve) that affects areas which that nerve supply (arm, leg) *** the right side and left side of the spinal column. These nerves are called nerve roots, or radicular nerves. They branch out at each level of the spine and innervate different parts of our body. This is why neck problems that affect a cervical nerve root can cause pain and other symptoms through the arms and hands (radiculopathy), and low back problems that affect a lumbar nerve root can radiate through the leg and into the foot (radiculopathy, or sciatica), thus prompting leg pain and/or foot pain.
A-Delta fibres aka re- classified? by Lloyd
group III (3 fibres)
C-fibres aka re-classified? by Lloyd
IV (4 fibres)
A-Delta -function (Erlanger/Gasser)
cutaneous - temp. - pain afferents *sharp/quick pain
A-Delta - funct (Lloyd) reclassified
Afferents from - deep pressure receptors (in mus.)