7.1: Chemotherapy Flashcards
1
Q
How does cisplatin chemotherapy act?
A
Alkylating agent
Forms a bond between the two DNA strands to prevent a replication fork being able to form, inhibiting DNA synthesis
2
Q
What are some examples of antimetabolite type chemotherapy agents?
A
5FU
Methotrexate
3
Q
How do antimetabolite agents work as chemotherapy?
A
Inhibit enzymes involved in DNA synthesis during the S phase of the cell cycle
4
Q
Which enzyme does 5-Flurouracil inhibit?
A
Thymidylate synthase
5
Q
Methotrexate inhibits which enzyme?
A
Dihydrofolate reductase (DHFR) (This enzyme acts to convert folate into purine bases for DNA synthesis)
