7.1 Anti Fungal

Question 1

Use as an systemic infection

MOA: Fungicidal, Binds to ergosterol

For luminal fungi

a. Amphoteriin B
b. Fluzytosine
c. Azoles

Answer 1

a

Question 2

Use as an systemic infection

MOA: Reduction of ergosterol synthesis by inhibition of fungal cytochrome p450 enzymes

For Cryptococcus meningitis

a. Amphoteriin B
b. Fluzytosine
c. Azoles

Answer 2

c

Question 3

Use as an systemic infection

MOA: Taken up by fungal cells via cytosine permease

For Vs C. neoformans

a. Amphoteriin B
b. Fluzytosine
c. Azoles

Answer 3

b

Question 4

For Mucocutaneous infections

MOA: Fungistatiic

For: Dermatophytes

a. Griseofulvin
b. Terbinafine
c. All of the above

Answer 4

c

Question 5

→ Yeast found as normal skin flora
→ Causes Pityriasis versicolor
→ Hypopigmented spots on chest and bac

a. Dermatophytes
b. Malassezia furfur

Answer 5

b

Question 6

→ Filamentous fungi
→ Trichophyton
→ Microsporum
→ Epidermophyton

a. Dermatophytes
b. Malassezia furfur

Answer 6

a

Question 7

Found as filamentous fungi in the environmental form but as yeasts in tissue form

a. Monomorphic fungi
b. Dimorphic fungi
c. Opportunistic fungi

Answer 7

b

Question 8

Example of dimorphic fungi are

Histoplasma
Coccidioides
Blastomyces

T or F

Answer 8

T

Question 9

Usually monomorphic forms, tend to take over hosts who are immunocompromised
a. Monomorphic fungi
b. Dimorphic fungi
c. Opportunistic fungi

Answer 9

c

Question 10

→ Aspergillus fumigatus
→ Candida albicans
→ Cryptococcus
→ Mucor, Rhizopus, Absidia
→ Pneumocystis Carinii

Examples of?

a. Monomorphic fungi
b. Dimorphic fungi
c. Opportunistic fungi

Answer 10

c

Question 11

MOA: Amphoteric compounds, interact with ergosterol forming artificial pores in membrane, disrupting membrane permeability

Resistance:
- resistance strains have low ergosterol content
a. Azoles
b. Griseofulvin
c. Terbinafine
d. Polyenes
e. Antimetabolite: Flucytosine

Answer 11

d

Question 12

Amphotericin B, Nystatin

a. Azoles
b. Griseofulvin
c. Terbinafine
d. Polyenes
e. Antimetabolite: Flucytosine

Answer 12

d

Question 13

MOA:
Fungicidal - Interfere with synthesis of ergosterol by inhibiting p450 of its precursor molecule, lanosterol

Resistance:
Decreased intracellular accumulation

a. Azoles
b. Griseofulvin
c. Terbinafine
d. Polyenes
e. Antimetabolite: Flucytosine

Answer 13

a

Question 14

Ketoconacole, Fluconazole, Itraconazole, Clotrimazole, and Miconazole

a. Azoles
b. Griseofulvin
c. Terbinafine
d. Polyenes
e. Antimetabolite: Flucytosine

Answer 14

a

Question 15

In Biodisposition, Only fluconazole penetrates the CSF

T or F

Answer 15

T

Question 16

MOA: Inhibits squalene epoxidase, therefore decreasing the synthesis of ergosterol

a. Azoles
b. Griseofulvin
c. Terbinafine
d. Polyenes
e. Antimetabolite: Flucytosine

Answer 16

c

Question 17

MOA: Activated by fungal cytosine deaminase to 5-FU

a. Azoles
b. Griseofulvin
c. Terbinafine
d. Polyenes
e. Antimetabolite: Flucytosine

Answer 17

e

Question 18

the use of combination is amphotericin B + flucytosine for severe candidal and cryptococcal infections (CNS penetration)

T or F

Answer 18

T

Question 19

MOA: Works via deposition in newly formed keratin, Disrupts microtubular structure of fungus

a. Azoles
b. Griseofulvin
c. Terbinafine
d. Polyenes
e. Antimetabolite: Flucytosine

Answer 19

b

Question 20

In griseofulvin, active only against dermatophytes orally, currently not recommended for the adult population, mostly for pediatric use

T or F

Answer 20

T