64: E.coli and Swine dysentery

Question 1

Requirements for successful therapy

Answer 1

• Clinical diagnostics
• Microbial diagnostics (common: polymicrobial)
• Culture + susceptibility testing –> Determine MIC
  > to select drug + dosage
  Factors to consider
  > Results of sensitivity tests
  > Pathogenecity
  > lesions, acuteness
  > PK, expense, toxicity of drug
  > Organ dydfunctions
  > Possible interaction

Question 2

Colibacillosis

Answer 2

Coliform of bacteria should be <10% of normal gut flora

Question 3

Swine E.coli

Answer 3

Major cause of illness and disease
3 phases:
> Neonatal diarrohea: 87P, K88
> Young piglet diarrhoea: K 88 
> Post weaning diarrhoea: K88 + edema disease: F18

Question 4

Poultry E.coli

Answer 4

Acute fatal septicemia

or subacute pancreatits or air sacculitis

Question 5

E. Coli types

Answer 5

Entero-toxigenic
Entero- invasive
Entero-pathogenic
Entero- Haemorhagic

Some stains have fibrial adhesions: adhere to and colonise SI ep. cells
> K88, K99, F18, 98 7P

Question 6

Colibacillosis

> Clinical signs

Answer 6

Watery diarrhoea (no blood)
Dehydration
Acidosis
Death
Lesions: Dyhdration and distention of the SI

Question 7

Prevention:

Answer 7

Immunising/vaccinations
Good hygeine + envirnomental conditions
Reduce predisposing facts (damp. chill)
Resistant pigs: have no receptor for K88

Question 8

colibacillosis: Therapy

Answer 8

Antibacts
Restore fluid + electrolyte balance (rehydrants)
Others: Zn oxide, water acidifiers, probiotics

Question 9

Antibacterials

Answer 9

Aminoglycosides: orally safe,
   >Problem: resistance in systemic infection
Phenicols: Flurofenicol only
Cephalosporins: 2+3rd generations
Fluroquinolones: Safe (not 1st choice)
Penicillins: safe, use in combo, broad spec
Polymyxins: Small spec, PO safe, 
      > ineffective against systemic inf
Sulphonamides: resistance
Tetracycline: resistance, use in combo
Lincosamides: Totally INEFFECTIVE

Question 10

Swine Dysentery : Clinical signs

Brachyspira hyodysenteriae

Answer 10

Anorexia, soft faeces, fever
Mucoid diarrhoea + blood
Dehydration, weakness, emastication

In older pigs( 12-75kg)

Question 11

Swine dysentery

Diagnosis

Answer 11

PM,smears
Differntiate from:
     > Lawsoma intracellularis,
     > salmonella, 
      > whip worm

Question 12

Swine dysentery

Prevention

Answer 12

Hygiene: regular disinfection, fly control
No mixing of population
Chemoprophylaxix—-> Post weaning: Lincomysin

Question 13

Swine dysentery

Treament

Answer 13

Carbadox (very active)
Chlortetracycline
Dimetridazole
Lincomycin
Monensin (V. active)
Saliomycin
Tiamulin, Tylvalsolin, valnemulin: 
       >Treatment and prophylaxis