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ANURBF LEC > [6] LESSON 11: CSF ANALYSIS > Flashcards

[6] LESSON 11: CSF ANALYSIS Flashcards

1
Q

 3rd major fluid in the body

A

CEREBROSPINAL FLUID

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2
Q

CEREBROSPINAL FLUID FUNCTIONS

A

 Serves as a mechanical barrier against trauma
 Provides supply of nutrients to CNS tissue
 Removes metabolic wastes

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3
Q

CEREBROSPINAL FLUID FORMATION

produced via active transport secretion and filtration by the [?] of each of the four ventricles of the brain  flows through the [?]  reabsorbed by the [?] into the [?]

A

choroid plexuses
subarachnoid space
arachnoid villi
superior sagittal sinus

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4
Q

rate of production:

A

0.3 to 0.4 ml/ min ~ 20 ml/hr

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5
Q

rate of production =

A

rate of absorption

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6
Q

Volume
 Adults:

A

140 to 170 ml or 90 to 150 ml

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7
Q

Volume
 Neonates:

A

10 to 60 ml

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8
Q

: routine method for CSF collection

A

 Lumbar Puncture

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9
Q

: collected from the sub-occipital region (cisterna magna)

A

 Cisternal Puncture

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10
Q

: used in infants with open fontanels

A

 Ventricular

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11
Q

 Between 3rd and 4th or 4th and 5th lumbar vertebrae

A

Lumbar Puncture

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12
Q

 Patient should be is a fetal position

A

Lumbar Puncture

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13
Q

Chemical and serological tests

A

CSF TUBE 1

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14
Q

Frozen at -15 to -30oC

A

CSF TUBE 1

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15
Q

Microbiological tests

A

CSF TUBE 2

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16
Q

Room Temp at 19 to 26 oC

A

CSF TUBE 2

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17
Q

Cell count

A

CSF TUBE 3

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18
Q

Refrigerated at 2 to 8 oC

A

CSF TUBE 3

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19
Q

Microbiology chemistry/serology

A

CSF TUBE 4

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20
Q

Microbiology  hematology  chemistry/serology

A

Low Volume CSF

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21
Q

Mix together

A

Excess CSF

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22
Q

Normal

A

Crystal clear

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23
Q

Meningitis

A

WBCs, Microorganisms

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24
Q

Disorders affecting the BBB

A

Protein

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25
Q

Radiographic contrast media

A

Oily

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26
Q

Hemorrhage

A

RBCs

27
Q

Old hemorrhage

A

Hemoglobin

28
Q

Production of IgG within the CNS

A

Protein

29
Q

Traumatic tap

A

RBCs

30
Q

Lysed cells from traumatic tap

A

Hemoglobin
Bilirubin

31
Q

RBC degradation

A

Bilirubin

32
Q

Increased serum levels

A

Carotene

33
Q

Meningeal melanosarcoma

A

Melanin

34
Q

Introduced by traumatic tap

A

Clotting factors

35
Q

Tubercular meningitis

A

Clotting factors

36
Q

Hazy, turbid, milky, cloudy

A

WBCs
Microorganisms
Protein

37
Q

Oily

A

Radiographic contrast media

38
Q

Bloody

A

RBCs

39
Q

Xanthochromic

A

Hemoglobin
Bilirubin
Carotene
Protein
Melanin

40
Q

Clotted

A

Protein
Clotting factors

41
Q

Pellicle

A

Protein
Clotting factors

42
Q

Blood distribution: Even in all tubes

A

INTRACRANIAL HEMORRHAGE

43
Q

Blood distribution: Decreasing RBC concentration from the 1st to the last

A

TRAUMATIC TAP

44
Q

Clot formation: Absent

A

INTRACRANIAL HEMORRHAGE

45
Q

Clot formation: Present

A

TRAUMATIC TAP

46
Q

Xanthochromic supernatant: Common

A

INTRACRANIAL HEMORRHAGE

47
Q

Xanthochromic supernatant: Not common

A

TRAUMATIC TAP

48
Q

Microscopic: Presence of erythrophages and siderophages

A

INTRACRANIAL HEMORRHAGE

49
Q

Microscopic: -

A

TRAUMATIC TAP

50
Q

D-dimer Test: Positive

A

INTRACRANIAL HEMORRHAGE

51
Q

D-dimer Test: Negative

A

TRAUMATIC TAP

52
Q

Clot formation + blood 

A

traumatic tap

53
Q

Clot formation but no blood 

A

meningitis, Froin’s syndrome

54
Q

Web-like/pine tree clot, no blood 

A

tubercular meningitis

55
Q

Pellicle formation 

A

suppurative meningitis

56
Q

—most frequently performed chemical test on CSF

A

Protein

57
Q

Protein Normal values: 6 months to adults

A

15 to 45 mg/dl

58
Q

Protein Normal values: Newborn

A

75 to 150 mg/dl

59
Q

Protein Normal values: > 60 y/o

A

> 60 mg/dl

60
Q

Normal Protein Fractions:

A

albumin (major), prealbumin (2nd), alpha-globulins (haptoglobin and ceruloplasmin), transferrin, tau protein, IgG and IgA

61
Q

(major)

A

albumin

62
Q

prealbumin (2nd)

A
63
Q

alpha-globulins

A

(haptoglobin and ceruloplasmin)

ANURBF LEC (9 decks)

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