6 Inflammation (1 hour) Flashcards
What are the initiator caspases? What are the executioner caspases?
8 (extra) and 9 (intra)
3
What is the anti-inflammatory cell death called?
Apoptosis
What are the scavengers following resolution? What are they activated by?
Alternative macrophages
Th2
What is the inflammatory type cell death called?
Necrosis
Leakage of contents causes inflammation
What exacerbates the inflammatory response to DAMPs
Alarmins
What is the sensor for the inflammasome? What caspase is involved? What does the inflammasome result in? What do these do?
NLRP3
Caspase 1
IL1 and 18
They are potent inflammatory cytokines
What is SIRS? What causes it? What are the symptoms?
Pathogenic overstimulation of the immune system
DAMPS or infectious origins
Shock or septic shock
What is the cytokine profile during SIRS?
C5a—> TNF—>IL1—>IL6
What is the gradual leveling out of inflammation response called?
CARS (compensatory anti-inflammatory response)
What is ALPS? What do we find? What are the symptoms?
Abnormal survival of lymphocytes causes by dysregulation of Fas pathway
Excess double negative T cells
Chronic lymphoproliferation, autoimmune disease