6 Inflammation (1 hour) Flashcards

1
Q

What are the initiator caspases? What are the executioner caspases?

A

8 (extra) and 9 (intra)

3

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2
Q

What is the anti-inflammatory cell death called?

A

Apoptosis

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3
Q

What are the scavengers following resolution? What are they activated by?

A

Alternative macrophages

Th2

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4
Q

What is the inflammatory type cell death called?

A

Necrosis

Leakage of contents causes inflammation

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5
Q

What exacerbates the inflammatory response to DAMPs

A

Alarmins

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6
Q

What is the sensor for the inflammasome? What caspase is involved? What does the inflammasome result in? What do these do?

A

NLRP3

Caspase 1

IL1 and 18

They are potent inflammatory cytokines

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7
Q

What is SIRS? What causes it? What are the symptoms?

A

Pathogenic overstimulation of the immune system

DAMPS or infectious origins

Shock or septic shock

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8
Q

What is the cytokine profile during SIRS?

A

C5a—> TNF—>IL1—>IL6

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9
Q

What is the gradual leveling out of inflammation response called?

A

CARS (compensatory anti-inflammatory response)

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10
Q

What is ALPS? What do we find? What are the symptoms?

A

Abnormal survival of lymphocytes causes by dysregulation of Fas pathway

Excess double negative T cells

Chronic lymphoproliferation, autoimmune disease

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