0 CD and IL

Question 1

IgM

Answer 1

B cells, first responders, pentamer, complement activation, J chain, 2nd most prevalent

Question 2

CD43

Answer 2

Immature B cells

Question 3

CD19

Answer 3

B cell marker

Question 4

IL7

Answer 4

Stimulates B, T, and NK
Comes from thymic stromal cells, bone marrow
Important for T cell survival

Question 5

CD3

Answer 5

All T cells

Question 6

CD4

Answer 6

Helper T cells

Question 7

CD8

Answer 7

CTL

Question 8

CD25

Answer 8

Unique to Treg (also has 4,3)

Question 9

IL5

Answer 9

Activates eosinophils; secreted by Th2

Question 10

IL3

Answer 10

Baso/eosinophil act., made by Mast cells

Question 11

IL4

Answer 11

Basophil activation, made by Mast and Th2, secondary macrophage act., B cell isotype switching to IgE

Question 12

IL1

Answer 12

Pyrogen, made by mast cell, main func hypothalamus fever,

Question 13

IL6

Answer 13

Made by mast; pyrogen; mainly acute phase (C reactive includ.)

Question 14

TNFalpha

Answer 14

Vasodilation and pathogen changes (insulin resistance, cardiac output down, increased vascular permeability), made by mast cells and Th1, activate neutrophils

Question 15

CD23

Answer 15

IgE receptor (allergies); on basophils and mast cells (main differentiator)

Question 16

CD16

Answer 16

NK cells

Question 17

CD56

Answer 17

NK cells

Question 18

CD80

Answer 18

Dendritic cells

Question 19

CD15

Answer 19

Neutrophils

Question 20

CD16b

Answer 20

Neutrophils

Question 21

IL8

Answer 21

Activate neutrophils, chemokine, binds integrin and causes changes

Question 22

C3a, C4a, C5a

Answer 22

C5a most potent, anaphylatoxins, SM contract., histamine degran., vasodilator release

Question 23

IL10

Answer 23

Regulatory cytokine, dendritic, made by Treg, macrophage

Question 24

TGFb

Answer 24

Made by Treg, can repair tissue without special cells present, regulatory cytokine

Question 25

IL13

Answer 25

Th2, alternative macrophage

Question 26

CD14

Answer 26

On macrophage, binds LPS of G- (TLR4)

Question 27

IL17A/F

Answer 27

Th17 makes it, pro-inflammatory

Question 28

IL22

Answer 28

Th17 makes it, pro-inflammatory

Question 29

IgG

Answer 29

Complement, most common, prevalent in 2o response

Question 30

IgA

Answer 30

Mucus, J chain, can be dimer (isn’t most of time)

Question 31

IgE

Answer 31

Binds blood basophils and tissue mast cells, CD23a and b affinity, asthma, allergies, worms

Question 32

IgD

Answer 32

B cells, no known function

Question 33

IL2

Answer 33

T cell autocrine signal to push towards survival and away from apoptosis; produced primarily by CD4+

Question 34

IL23

Answer 34

Functions to differentiate Th17

Question 35

IFNa

Answer 35

Produced by leukocytes; degrade mRNA nonspecifically

Question 36

IFNb

Answer 36

Produced by fibroblasts; degrade mRNA non-specifically

Question 37

IFNg

Answer 37

Type 2 IFN, secreted by NK and Th1, activates macrophages

Question 38

IL12

Answer 38

secreted by Th1, activate macrophages, causes more Th1 to be made

Question 39

IL2

Answer 39

Binds to CD25, produced by TH1, promotes proliferation of T cells

Question 40

IL15

Answer 40

activates NK; required for survival of memory T

Question 41

CD25

Answer 41

Expressed in high conc. on Treg, binds IL-2

Question 42

IL1/18

Answer 42

Made in response to inflammasome and they are potent inflammatory cytokines

Question 43

Malnutrition lowers

Answer 43

IL4 and 10

Question 44

CD103

Answer 44

Dendritic cells needed in mucosa for tolerance

Question 45

Needed for mucosal tolerance

Answer 45

TGFb and retinoic acid from CD103+ DC

Question 46

CD152

Answer 46

CTLA4

Question 47

CD32

Answer 47

IgG receptor on B that is inhib

Question 48

CD16b

Answer 48

On NK and functions in IgG mediated ADCC

Question 49

CD27

Answer 49

Increases in memory B