10 Host Defense (1 Hour)

Question 1

What are the 5 broad categories of microbes?

Answer 1

Extracellular bact, intra. bact., fungi, viruses, parasites

Question 2

What innate immunity mechanisms protect against extracellular bacteria?

Answer 2

Alternative complement, mannose-lectin complement, epithelial barriers and normal flora, phagocytes (neutro and macro), pro-inflammatory cyto/chemokines, PAMPs

Question 3

What mechanism prevents the physical spreading of bacteria?

Answer 3

Clotting and fibrin formation

Question 4

What adaptive cells respond to extracellular bacteria?

Answer 4

CD4 T and B cells

Question 5

What two factors cause Ab to clear extracellular bacteria more quickly?

Answer 5

Ab for opsonization and Ab for opsonization and complement act.

Question 6

How do Ab interfere with the mechanism of extracellular bacteria?

Answer 6

Block attachment to host cell membrane, triggers complement, block surface transport proteins on bact., acts as opsonin, block bacterial factors that interfere with chemotaxis or phago., neutralize bacterial toxins