3 Immune Receptors and Signal Transduction (1 Hour) Flashcards
What is CD40 involved in?
B cell isotype switching (CD40 on B cell and CD40L on T cell)
What does CD40 ligand def. and CD40 def. result in?
B cell isotype switching issues
CD3gamma def. results in
No T cell dev. = early onset SCID
CD8 def. causes
Inability to clear EBV
ZAP-70 def causes
Recurrent infections and poor survival past 2 years
What signaling method do immune receptors have in common?
ITAM activating motifs (immunoreceptor tyrosine based activating motifs)
Where is FcgammaRIIB found?
B cells and myeloid cells
What 3 pieces compose a TCR?
the TCR itself, CD3 (either epsilon/gamma or epsilon/delta) and the double zeta segment
What portions of the TCR complex can signal
CD3 and double zeta sections
What does CD4 and CD8 do in MHC2 and MHC1 reactions?
It is costimulatory
The Ras-MAP cascade features what main players?
ZAP-70->PLC—> increased Ca—>AP1
What is the pathway to NFAT activation?`
ZAP70->PLC->increased Ca->increased calcineurin->NFAT
What is the BCR complex?
An Ig that is stuck in the surface and a Igbeta/Igalpha domain for signaling
Which of the following TF is already in the nucleus: NFAT, NFkB, AP-1?
AP1
What transcription factor moves to the nucleus and utilizes PKC and PLC
NFkB
