6 Eye (and associated structures) Flashcards
Fibrous coat consists of?
cornea, sclera
Uvea consists of?
choroid, ciliary body, iris
Where are Meibomian glands found?
In tarsal plate
Classify conjunctiva epithelium?
Stratified columnar w/ goblet cells
T/F conjunctiva is found on both the eye and eyelid?
True
Eyelashes have what kind of glands?
sebaceous (just like any other hair follicle)
Eyelids have what kind of glands?
- Apocrine sweat glands (like armpit and perianal)
- Meibomian glands (oily secretion to seal lid closed)
Eye socket has what kind of gland? Classify this gland? What characteristics do its secretions have?
- Lacrimal (1 in lateral upper corner, accessory ones on inner surface of upper eyelid)
- Serous acini
- alkali w/ lysozymes
Path of tears exiting the eye?
lacrimal punctum-> sup/inf canaliculus-> common canaliculus-> lacrimal sac-> nasolacrimal duct
Retina consists of?
- Rods, cones
- Ciliary and iridial (nonvisual)
What are 4 light-bending parts of eye?
- Anterior cornea
- Lens
- Aqueous humor (anterior to lens)
- Vitreous body (posterior to lens)
Vitreous body consists of?
- collagen
- GAGs
- fibroblasts
- macrophages
Hyperopia requires what kind of prescription lens?
convex (positive diopters)
Astigmatism is?
unequal cornea or lens curvature
Classify sclera tissue? Its main job is?
- dense irregular con. tissue w/ glycosaminoglycans
- Maintain shape of eye
What do rectus muscles attach to?
Sclera
Lamina cribrosa is what?
- multilayered collagen fibrils that insert into scleral canal wall where the optic nerve penetrates the sclera
- Weaker than rest of sclera (displaces posteriorly in glaucoma)
Tenon’s capsule consists of?
connective tissue (in which eye rotates)
Name the cornea layers superficial to deep? What is unique about each layer?
- tears
- epithelium (5 cells thick)
- Bowman’s membrane a.k.a. basement membrane of the epithelium (collagen w/ glycosaminoglycans)
- Stroma a.k.a. lamina propria (collagen, keratocytes and phagocytic cells)
- Descemet’s membrane a.k.a. basement membrane of the endothelium (elastic, collagen increases w/ age)
- endothelium (pumps H2O out, nutrients in to keep transparency)
Where is the trabecular meshwork and Schlemm’s canal found? Their function?
- Limbus
- Drains aqueous humor
What produces aqueous humor? what is its composition?
- Non-pigmented ciliary process cells
- Like plasma but less protein
Dif between closed and open angle glaucoma?
- Closed=block in trabecular meshwork or between pupil and iris prevents flow. These are located at the “angle” of the eye, thus “closed angle”.
- Open=Not blocked. Just drains slowly due to up venous pressure or microobstruction.
Open or closed glaucoma more common? which is silent?
- Open (60%)
- Open
What is the 3rd type of glaucoma?
Developmental.
Iris (part of uvea) stroma consists of?
-Stroma: fibroblasts, collagen, melanophores (ant. iris), clump cells (phagocytes)
Iris (part of uvea) pigment epithelium consists of?
iridial retina (nonvisual)
Iris muscles are called what?
Sphincter (Parasympa), Dilator (Sympa)
Study the anatomical pictures.
Good job :)
What covers the ciliary body?
- 2 retina layers, superficial to deep:
- -Nonpigmented (secretes aqueous humor)
- -pigmented
Voluntary thickening of the lens is called? This is a parasympathetic relaxation of what?
- Accomodation
- It is a relaxation of the lens, but it is a CONTRACTING of Circular Band of muscle
What muscle flattens the lens? (for far vision)
-Radial-meridional (sympathetic)
What fibers attach ciliary body to lens?
Zonule fibers
Choroid consists of what layers? (outermost to innermost)
-Suprachoroid layer (binds to sclera)
-Vessel layer w/ melanocytes
-choriocapillary layer
-Bruch’s membrane
Note: choroid layer is known as the vascular layer of the eye
presbyopia is?
hardening of lens by condensation of lens fibers (lose near vision)
Common cause of cataracts?
Radiation (sun) exposure
source of lens fibers?
germinal zone
Pigmented epithelium has what origin?
Neuroepithelium
What is the direct path once a beam of light hits a photoreceptor?
- Photoreceptor
- Bipolar
- Retinal ganglion cell
What is a mnemonic for the retinal cell types from deep to superficial?
- Photos (Photoreceptors)
- Make (Muller’s go from here to same layer as ganglion cells)
- Home (Horizontal)
- Bright (Bipolar)
- And (Amacrine)
- Gay (Ganglion)
Mnemonic for Retinal layers from inside to outside?
-I never give in, I often overcome every persons request
(Internal limiting membrane, nerve fiber layer, ganglion cell layer, inner plexiform layer, inner unclear layer, outer plexiform layer, outer nuclear layer, external limiting membrane, photoreceptors receptors, RPE.
-Note that plexiform layers contain only axons, while nuclear and ganglion layers contain only cell bodies
Vitamin A is part of what? In what layers? In rods, cones, or both?
- Rhodopsin
- Pigment layer and photoreceptor layers
- Rods
What is the site of retinal detachment?
pigmented epithelium
Pigmented epithelium is deep to what retinal layer?
Photoreceptor layer
Does the pigment layer absorb light?
Yes (in granules)
Rhodopsin is a combination of what? What color is it?
- Opsin and Retinaldehyde (vit. A derivative)
- Visual purple (absorbs blue green light)
T/F Rhodopsin is less absorptive than iodopsin?
false
Converting 11-cis retinal to trans triggers what?
conformation change in opsin ->
G-protein cascade
What are the 3 iodopsins in cones?
Red, green, blue
We have more rods? or cones?
Rods
Lamellar plates of 11-cis-retinal are regenerated where? Phagocytosed where?
- RPE
- RPE
What does the “Inner segment” of a cone/rod do?
metabolism
Retinitis pigmentosa is what?
Loss of photoreceptor cells (usually rhodopsin mutation but 35 others possible)
which retinal cells have an integration function for visual stimuli?
horizontal and amacrine
Characterize the 2 forms of macular degeneration?
Wet-blood vessels grow up from the choroid behind the retina (worse form)
Dry-Drusen and dead RPE cells accumulate between the retina and choroid, killing photoreceptor cells
What does retinal hypoxia cause? What might lead to hypoxia?
- Hypervascularization, microaneurysms, bleeding, edema
- Diabetes