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HOS Unit 3 > 5 Lymphoid Tissue > Flashcards

5 Lymphoid Tissue Flashcards

1
Q

T-F– plasma cells are included in b cell lymphocyte category?

A

True

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2
Q

Are natural Killers a lymphocyte?

A

yes

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3
Q

Why is it called B cells?

A

bursa fabricus in birds

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4
Q

T-F–Thymus functions primarily in first 15 years of life.

A

True- maturation and selection of T cells

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5
Q

Where is MALT found?

A

naso oropharynx
GI Tract
Lung- respiratory system

Urogenital

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6
Q

T or F- Naive lymphocytes cells divide?

A

false- not dividing is what defines them

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7
Q

Where are homing receptors for lymphocytes found?

A

high-walled endothelial venules

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8
Q

T- F- lymphatic vessels also carry tissue fluid containing antigens from peripheral tissues to the lymph nodes?

A

True

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9
Q

What does the hilum of the lymph nodes contain?

A

Enter- arteries and nerves

Exit- veins and efferents

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10
Q

Besides t lymphocytes, what is found at the paracortex?

A

post-capillary venules that allow T lymphocytes to migrate into node.

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11
Q

What do medulla cords contain?

A

B lymphocytes, plasma cells, macrophages

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12
Q

What are lymph node sinus partially lined by?

A

reticular cells and macrophages

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13
Q

B lymphocytes make up what percentage of circulating lymphocytes?

A

10-20%

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14
Q

What is the earliest sign of B cell differentiation?

A

rearrangement of immunoglobulin heavy chain

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15
Q

T or F- after rearrangement of the immunoglobulin heavy chain, there is rearrangement of both the lambda and kappa light chains at the same time?

A

False– only one rearranges at first. kappa or lambda

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16
Q

Naive B cells express what Ig?

A

IgM and IgD

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17
Q

What layers are found around the germinal follicle?

A

mantle and then marginal

18
Q

What makes up the dark zone of the germinal center?

A

proliferating centroblasts that form into centrocytes

19
Q

T or F- memory cells are also produced in the germinal center?

A

True

20
Q

What is a centroblast?

A

Activated B cell that is proliferating.

21
Q

What is an enlarged lymph node caused by benign or malignant conditions? difference in viral vs. bacterial?

A

Lymphadenopathy

  • -follicular hyperplasia seen in bacterial infections
  • -viral infections lead to parafollicular hyperplasia
22
Q

What is normally 150 grams, has thin fibrous capsule, cut surface red with gray specks, and stroma reticular connective tissue?

A

Spleen

23
Q

What is red pulp transversed by?

A

thin walled vascular sinuses separated by cords

24
Q

What type of circulations does the spleen have?

A

Open and closed

25
Q

Is the open component the fast component of spleen circulation?

A

No it is the slow component

26
Q

What splenic blood circulation is defined by capillary flow into splenic cords then filtered in sinusoids to reach veins?

A

Open circulation

27
Q

What splenic circulation pathway has direct passage from pencillary arteries to the sinus and then to trabecular veins?

A

Closed circulation—MOST OF THE CIRCULATION

28
Q

What does red pulp do?

A

REMOVAL OF UNWANTED ELEMENTS FROM THE BLOOD

-senescent red cells, damaged red or white cells, bacteria, cell debris

29
Q

What lymphoid cell region is located more near to the central arteriole in the spleen?

A

T cell region

30
Q

In the spleen, what are the layers of lymphoid tissue in order from central to eccentric?

A

T cell region
B cell Region
marginal sinus- surrounds B and T cell zones
marginal zone- contains macrophage and lymphocytes

31
Q

What 2 things are commonly seen in asplenic people?

A

1 risk for bacterial infections

2 have abnormal red cell inclusions- howell jolly bodies

32
Q

What pharyngeal pouches is thymus derived from?

A

3rd and 4th

33
Q

of thymus lobes?

A

2—then divided into lobules

34
Q

What types of cells are found in the thymus?

A

T lymphocytes
Thymic epithelial cells
Macrophages - for apoptotic thymocytes
DEndritic cells

35
Q

What are whorls of epithelial cells seen in medullary region called?

A

Hassall’s corpuscles

36
Q

Where does major proliferation happen of T cells in the thymus according to these lecture notes?

A

subcapsular space

37
Q

Where does interaction of MHC occur according to these notes in the thymus for reactivity testing?

A

deeper layer of cortex-thymic epithelial cells

38
Q

T cells are what percentage of circulating lymphocytes?

A

60-70%

39
Q

What syndrome causes absence of 3 and 4 pharyngeal pouches?

A

DiGeorges Syndrome

40
Q

Is Malt encapsulated as lymph nodes are?

A

No

41
Q

What major antibody is secreted by MALT system?

A

IgA

HOS Unit 3 (9 decks)

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