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Mercy CLS 4: Blood Bank > 6. Donor selection & processing > Flashcards

6. Donor selection & processing Flashcards

1
Q

donor temperature requirement

A

≤37.5° C or ≤99.5° F

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2
Q

HR requirement

A

50-100 bpm, or 40-49 if a healthy athlete

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3
Q

BP requirement

A

90-180 systolic/50-100 diastolic

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4
Q

hemoglobin requirement

A

≥12.5 g/dL (female) or ≥13 g/dL (male)

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5
Q

hematocrit requirement

A

≥38% (female) or ≥39% (male)

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6
Q

vCJD permanent deferral

A

Lived in the UK from 1980-1996

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7
Q

receiving …… results in permanent deferral (4)

A

stem cell transplant
dura mater
human pituitary GH
xenotransplant product

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8
Q

infectious disease permanent deferrals (4)

A

HBsAg confirmed positives
Repeat reactive anti-HBc
Infection with HIV, HCV, or HTLV
History of babesiosis

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9
Q

aseptic technique is most important for which blood products?

A

platelets
stored at room temp

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10
Q

aseptic technique procedure (4)

A
  1. Scrub venipuncture site 2 inches in all directions from center for 30 seconds with iodine swab. For allergic donors, you can use chlorhexidine.
  2. Using a second swab, start at the center and move outward in a concentric spiral 1.5 inches in all directions.
  3. Let stand for at least 30 seconds to allow for bactericidal action.
  4. Cover the prepped skin site with on sterile 2x2 gauze.
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11
Q

cannot be made from long draw (15-20 mins)

A

FFP

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12
Q

common donor reactions

A

lightheadedness
dizziness
nausea
skin rash/irritation

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13
Q

donor reactions causing the donation to be stopped

A

vomiting
chills
hyperventilation
fainting
convulsions

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14
Q

uncommon adverse donor events

A

hematoma
arterial puncture
nerve injury

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15
Q

hemoglobin requirement for autologous donation

A

11 g/dL

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16
Q

autologous donor units do not require normal infectious disease testing if…

A

staying at the same facility

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17
Q

irradiating directed donations from blood relatives prevents…

A

transfusion-associated graft vs host disease (TA-GVHD)

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18
Q

Performed to decrease the red cell volume

A

therapeutic phlebotomy

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19
Q

therapeutic phlebotomy indications

A

polycythemia
hemochromatosis

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20
Q

therapeutic phlebotomy blood can be used for donations if patient has…

A

Hereditary hemochromatosis

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21
Q

indications for therapeutic apheresis for plasma

A

Goodpasture’s
TTP
acute Guillian-Barre

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22
Q

indications for therapeutic apheresis for red cells

A

sickle cell
methemoglobin

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23
Q

ALL infectious disease testing required on donor units (8)

A
  • 3 Hepatitis B tests (HBV DNA, HBsAg, Anti-HBc)
  • 2 Hepatitis C tests (HCV RNA, Anti-HCV)
  • 2 HIV tests (HIV-1 RNA, Anti-HIV-1/2)
  • Syphilis (RPR)
  • HTLV (Anti-HTLV I/II)
  • Trypanosoma cruzi; at least once per donor
  • West Nile Virus (WNV-RNA)
  • Babesias; endemic states only
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24
Q

HLA 1/2 testing female donors prevents…

A

transfusion-related acute lung injury (TRALI)

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25
Q

donors 16-18 years of age special test

A

ferritin

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26
Q

pRBC (AS) shelf life

A

42 days

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27
Q

pRBC (CPDA-1) shelf life

A

35 days

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28
Q

pRBC (CPD) shelf life

A

21 days

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29
Q

frozen RBC with 40% glycerol shelf life

A

10 years

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30
Q

thawed frozen RBC shelf life

A

24 hours

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31
Q

washed RBCs shelf life

A

24 hours

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32
Q

FFP & plasma frozen w/i 24h shelf life (frozen)

A

1 year

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33
Q

FFP & plasma frozen w/i 24h shelf life (thawed)

A

24 hours

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34
Q

thawed plasma shelf life
(not “FFP”)

A

5 days

35
Q

liquid plasma shelf life

A

CPD: 26 days

CPDA1: 40 days

36
Q

cryo AHF (frozen) shelf life

A

1 year

37
Q

cryo AHF (thawed) shelf life

A

6 hours in same bag

4 hours pooled

38
Q

platelet concentrates shelf life

A

5 days

39
Q

pooled platelet concentrates shelf life

A

4 hours

40
Q

apheresis platelets shelf life

A

7 days

41
Q

granulocytes shelf life

A

24 hours

42
Q

products stored at 1-6° F (6)

A
  • pRBCs
  • thawed frozen RBCs
  • washed RBCs
  • thawed FFP & plasma frozen w/i 24h
  • thawed plasma
  • liquid plasma
43
Q

products stored at ≤ -65° (1)

A
  • frozen RBCs
44
Q

products stored at ≤ -18° (3)

A
  • FFP (frozen)
  • plasma frozen w/i 24h (frozen)
  • cryo AHF (frozen)
45
Q

products stored at 20-24° (3)

A
  • cryo AHF (thawed)
  • platelet products (in continual motion)
  • granulocytes
46
Q

products stored at 1-6° can be shipped at ——°, using…

A

1-10°
wet ice

47
Q

frozen products shipped to maintain frozen state use…

A

dry ice

48
Q

desired unit volume

A

450-550 mL

49
Q

low volume unit
product prepared

A

342-449 mL
pRBCs only

50
Q

unexpected conditions that can affect donations (4)

A

Severely lipemic units may not be able to be tested
Long draw may cause clots in pRBC
Hemolysis
Foreign objects (ie broken cannula)

51
Q

WBCs in leukocyte-reducted product

A

< 5 x 10^6

52
Q

Platelets collected by apheresis are WBC reduced by…

A

the continuous flow separation process

53
Q

CMV safe if filtered within—–days of collection

A

3-5

54
Q

leukocyte reduction reduces risk of… (3)

A

febrile nonhemolytic transfusion reactions
CMV transmission
HLA alloimmunization

55
Q

Explain process for making pRBCs, platelets from WB, and FFP (6)

A
  1. Start with WB at RT—light spin
  2. PRP (platelet rich plasma) is expressed into 3rd bag
  3. AS is added to RBCs; pRBC bag is cut off
  4. Heavy spin on PRP bag
  5. Plasma is expressed into 2nd bag; FFP bag is cut off and frozen
  6. Platelet bag rests for 1 hour and is massaged; then put on rotator
56
Q

female plasma

A

salvaged plasma

57
Q

long draw, low volume, not processed within 24 hours plasma

A

salvaged plasma liquid

58
Q

names for platelets from WB

A

“Random donor platelets”
”WB-derived platelets”

59
Q

Explain process for making cryoprecipitate via separation-insolubility at low temperatures

A
  1. Allow FFP to thaw at 1-6° until slushy; cryo precipitates out
  2. Hard spin
  3. 2nd bag hangs off counter, and CP (cryo-poor) plasma rapidly flows into it, leaving cryo and 15 mL plasma in the 1st bag
  4. CP plasma is discarded (usually)
  5. Cryo is frozen
60
Q

name of the process for making cryo

A

separation-insolubility at low temperatures

61
Q

open system expirations

A

24-hour expiration at 1-6°
4-hour expiration at 20-24°

62
Q

4 things required on each donor unit label

A

Unit number
Component code
ABO/Rh type
Expiration date

63
Q

Explain parts of the unit number

A

W — collected in the USA
Next 4 numbers — facility code
Next 2 numbers — year
Sequential number for each unit collected in one year
00 and boxed number are for lab process control

64
Q

pRBC indications (2)

A

symptomatic anemia
reduced O2 carrying capacity

65
Q

function of glycerol in freezing RBCs

A

protects the RBCs from freezing injury by reducing the formation of ice crystals and preventing intracellular dehydration and volume reduction

66
Q

RBC units for freezing are frozen within —- days of collection

placed in freezer within —- hours of glycerol addition

A

6 days

4 hours

67
Q

Bacterial contamination management of —— is required

A

platelets

68
Q

expected count for random donor platelets

A

> 5.5 x 10^10

69
Q

storage volume of apheresis platelets

A

100-400 mL

70
Q

explain bacterial contamination management for apheresis platelets

A

Blood cultures collected 24-36 hrs
Initial results for labeling after 20 hrs

71
Q

apheresis platelet count

A

3 x 10^11

72
Q

aphereis platelets approximately equal to —– random donor platelets

A

4-8

73
Q

apheresis platelets are visually inspected for…

A

platelet clumps, discoloration, or excessive lipemia

74
Q

platelets indications (4)

A

thrombocytopenia
abnormal platelet function
DIC
prevention of bleeding from bone marrow hypoplasia

75
Q

expected platelet increment after one transfusion of random donor platelets

A

5,000 to 10,000/uL

76
Q

granulocyte indications (2)

A

low WBC count
infection that does not respond to antibiotics

77
Q

average FFP volume

A

250 mL

78
Q

FFP indications (4)

A

general coagulation deficiency
liver disease
TTP
massive transfusion

79
Q

only difference plasma frozen w/i 24h has from FFP in composition

A

reduction in levels of labile coagulation factors V and VIII

80
Q

cryo indications (2)

A

decreased fibrinogen (DIC or massive bleeding)
secondary tx for hemophilia A & vonWillebrand disease if specific factors are not available

81
Q

given for volume replacement

A

albumin

82
Q

albumin lacks…

A

Ig
coagulation factors

83
Q

IVIg indications

A

weakened immune systems (lupus, multiple sclerosis, etc)

84
Q

factor concentrate indications

A

Factor deficiencies (FVIII, vWF, FXIII, etc)

Mercy CLS 4: Blood Bank (13 decks)

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