6/17 Flashcards
bordatella sp.
bronchiseptica
avium
bordatella bronchiseptica
facultative pathogen
aerobic
affinity for cilated respiratory epithelium
many animal species
main pathology in b bronchiseptica
dogs kennel cough
pigs atrophic rhinitis
B. bronchiseptica viurlence
adehesins to cilated respiratory epithelium
filamentous hemagglutinin, peractin, fimbriae role unclear
biofilms
fe capture
B. bronchiseptica viurlence- toxins
toxins
hemolysin
dermonecrotic toxin* skin necrosis damage osteoblasts and nasal tissue
osteo toxin osteoblasts as well
tracheal cytotoxn destruction of ciliated epithelium
B. bronchiseptica viurulence- phase variation
BVG regulon
phase variation
virulent to non virulent
coordinate expression or not of virulence genes
low tempMg sulfate nicotinic acid (limit expression)
non progressive atrophic rhinitis in pigs
damage of nasal mucosa
demonecrotic toxin prod
prod of mucus
pneumonic bordetellosis in pigs
no fever morbidity high mortality variable to high coughing and dypsnea age > 1 wk secondary inf