6

Question 1

oxandrolone

Answer 1

anabolic steroid

i: promote weight gain in debilitated, HIV related cachexia, anemia, promote protein anabolism in LT corticosteroid
ta: analogue of testosterone - tissue-building effect of testosterone w/ less androgenic effect, inc hemoglobin and RBC
ci: CAD, prostate/male breast cancer, liver dysfx, preg/lact / BBW - liver tumor, hepatitis, lipid lv - cardiac dz
c: x
ae: gynecomastia, testicular atrophy, priapism, baldness, libido change, prostate cancer risk ; female testosterone effect; personality change, liver dysfx, sexual dysfx, weight gain, insomnia
di: dec dose OAC, OP DM med; inc dose lipid-lowering med
ni: LFT and cholesterol baseline Q6month, illegal doping

Question 2

sildenafil

Answer 2

ED drug

i: ED, pulmonary HTN
ta: inc nitrous oxide in corpus cavernosum, relax smooth muscle and blood flows to corpus cavernosum - erection
ci: penis obstruction, priapism risk, penile implant,
c: CAD, PUD, HTN, hypoT, bleeding dz, hepatic/renal dz
ae: HA/dizzy, UTI, flushing, rash, dyspepsia, diarrhea, hearing loss, vision change
di: grapefruit dec absorption, nitrate/alpha adrenergic blocker CV/fatal hypoT
ni: x