5.6b

Question 1

Funx of EGF?

Answer 1

maintenance and maturation of intestinal mucosa

Question 2

Funx of HB-EGF?

Answer 2

Inhibits apoptosis following inflammatory damage.

Initiates repair mechanisms following hypoxia, ischemia.

Question 3

Funx of neuronal GF?

Answer 3

regulate enteric nervous sys, peristalsis (BDNF), prolife of ENS (GDNF)

Question 4

Funx of EPO and IGF1/2

Answer 4

increase RBC/Hematocrit, VEGF stimulates GI angiogenesis

Question 5

Funx of GCSF

Answer 5

Stimulates trophic changes and enterocyte proliferation

Question 6

Role and funx of TGF-beta

Answer 6

Most abundant cytokine in breast milk.
Initiates repair mechanisms.
Remodeling may generate anti-allergenic effect in infant.

Question 7

funx of TNFalpha

Answer 7

Most prevalent pro-inflammatory cytokine.

Largely bound to soluble TNF receptors

Question 8

funx IL6 and IL8

Answer 8

Associated with systemic inflammation and fever in mother.

Recruits neutrophils

Question 9

What does the ratio of INFg:IL-13 correlate with?

Answer 9

inversely correlated to allergic status of mother