5.02 Urology - The Kidney Flashcards
What is pyelonephritis?
Inflammation of the kidney parenchyma and the renal pelvis, typically due to bacterial infection.
Explain the pathophysiology of pyelonephritis.
Acute pyelonephritis resulting from bacterial infection within the renal pelvis and parenchyma, which have ascended from the lower urinary tract or invaded from the blood stream or lymphatics.
Neutrophils infiltrate the parenchyma and cause inflammation.
What is the most common cause of pyelonephritis?
Bacterial - Escherichia coli
What are the risk factors for pyelonephritis?
- obstructed urinary tract
- neuropathic bladder injury
- female gender (short urethra)
- indwelling catheter
- immunocompromised (e.g. diabetes mellitus, corticosteroid use)
- renal calculi
- sexual intercourse
- menopause (ie. oestrogen depletion)
What are the clinical features of pyelonephritis?
Classic triad of:
- fever
- unilateral loin pain
- nausea and vomiting
Pts may also have symptoms of lower urinary tract infection.
What are the differentials for pyelonephritis?
Any patient presenting with back pain and tachycardia / hypotension should be assessed for potential ruptured AAA.
What are the investigations of pyelonephritis?
- urinalysis (assess for nitrites and leucocytes)
- urinary beta-hCG in women of child-bearing age
- urine culture
- routine bloods (e.g. FBC and CRP for inflammation; U&Es to assess renal function)
- renal US for evidence of obstruction
- CT KUB (non-contract CT imaging) to assess for obstruction
How is pyelonephritis managed?
- empirical antibiotics
- prescribe suitable analgesia
- consider admission if unstable or immunocompromised
What are the complications of pyelonephritis?
- severe sepsis
- preterm labour in pregnant ladies
- chronic pyelonephritis
What is emphysematous pyelonephritis?
A rare form of pyelonephritis caused by gas-forming bacteria, associated with a high-mortality rate.
Presents similarly to acute pyelonephritis but fails to respond to empirical antibiotics. CT imaging shows gas within the kidney.
Why is emphysematous pyelonephritis more common in diabetic patients?
Hyperglycaemic state promotes CO2 production from fermentation by enterobacteria.
What is the difference between simple and complex renal cysts?
Simple cysts have a well-defined outline and are thought to develop from the renal tubule epithelium.
Complex cysts have more complicated structures and have a risk of malignancy.
What are the risk factors for renal cysts?
- increasing age
- smoking
- hypertension
- male gender
- gentics
Which specific genetic conditions increase the risk of renal cysts?
- polycystic kidney disease
- tuberous sclerosis
What inheritance pattern does polycystic kidney disease display?
Autosomal dominant polycystic kidney disease (ADPKD) most common.
Can be autosomal recessive but more rare.
ADPKD is caused by mutations of which genes specifically?
PKD1 and PKD2 genes
What are the clinical features of renal cysts?
Found incidentally on abdominal imaging - often asymptomatic.
May cause flank pain or haematuria.