5.01 Urology - Presentations Flashcards
What is haematuria and how can it be classified?
The presence of blood in the urine.
Either visible (seen by the naked eye) or non-visible (confirmed by urine dipstick or urine microscopy).
Give some possible causes of haematuria?
- urinary tract infection
- renal cancer
- bladder cancer
- renal calculi
- prostate cancer
- benign prostatic hyperplasia
- glumerulonephritis
What is pseudohaematuria?
Red or brown urine that is not due to the presence of blood in the urine.
Causes include medication (e.g. rifampicin), hyperbilirubinaemia, and foods (e.g. beetroot).
How should haematuria be investigated?
Urinalysis - presence of nitrates and/or leukocytes indicates infection as potential underlying cause.
Baseline bloods (FBC, U&Es, clotting, PSA).
Abdominal examination and DRE.
Following urological referral, flexible cytoscopy can be used to assess the lower urinary tract. Ultrasound imaging and CT urograms may also be used to image the upper urinary tract.
Give some causes of lower urinary tract symptoms (LUTS).
- BPH
- UTI
- bladder cancer
- prostate cancer
- detrusor muscle weakness
- prostatitis
Give the storage LUTS.
- increasing urinary frequency
- nocturia
- increased sense of urgency
- urge incontinence
Give the voiding LUTS.
- hesitancy or straining in mictruition
- poor flow
- terminal dribbling
- feeling of incomplete emptying
Give some clinical features that may be associated with LUTS.
- visible haematuria
- suprapubic discomfort
- medication history
What tool can be used to assess and monitor the impact of LUTS on quality of life in men?
International Prostate Symptom Score
What general investigations are warranted for a patient presenting with LUTS?
- bladder diary
- urinalysis and urine culture
- routine blood tests (including FBC & U&Es; PSA)
What specialist investigations are warranted for a patient presenting with LUTS?
- urodynamics to assess flow rate, detrusor pressure, and storage capacity
- cystoscopy
- upper urinary tract imaging (ultrasound, CT)
How are LUTS managed?
- regulate fluid intake
- urethral milking
- double voiding
- pelvic floor exercises
- bladder training techniques
What is the MOA of anticholinergics in the treatment of LUTS?
Relax the bladder by opposing parasympathetic cholinergic control of contraction.
First line in patients with overactive bladder - e.g. oxybutynin
What is the MOA of tamsulosin and finasteride in the treatment of LUTS?
Tamsulosin is an alpha blocker;
Finasteride is 5a-reductase inhibitor;
Reduces prostate size by relaxing prostate muscle.
What is acute urinary retention?
The new onset inability to pass urine, subsequently leading to pain or discomfort.
What is the most common cause of acute urinary retention?
- BPH
May also be caused by:
- prostate cancer
- UTI (causes urethral sphincter to close)
- constipation (compresses urethra)
- severe pain
- anti-muscarinic medication
- peripheral neuropathy
What are the clinical features of acute urinary retention?
- acute suprapubic pain
- inability to micturate
OE palpably distended bladder, with suprapubic tenderness. DRE performed to assess for any prostate enlargement or constipation.
How is acute urinary retention investigated?
- post-void bladder scan
- routine bloods (e.g. FBC, CRP, U&Es)
- CSU for microscopy
- USS to assess for hydronephrosis