5. Longevity and Health Flashcards
Includes chapter 5
what are maximum and average longevity?
- maximum longevity - the oldest age to which any individual of a species lives (about 120 right now)
- average longevity - the age at which half of the individuals who are born in a particular year have died
what are the main factors influencing longevity?
- genetics
- gender
- environment
what is active life expectancy (healthspan) and dependent life expectancy?
- active life expectancy (healthspan) - refers to years living in a healthy state
- dependent life expectancy - refers to remaining years living in a dependent state
what is some evidence that genetics contribute to longevity?
- the parents and siblings of people who live till 90 were less likely to die young, but there was no impact on spouses
- after the age of 60, genetics increasingly influences lifespan for twins, and there is more of similarity between identical twins than fraternal twins
how does gender affect longevity?
- in developed countries, women tend to live much longer than men (about 5 years)
- in developing countries, life expectancy is almost equal
- women often die in childbirth and baby girls are more unwanted
what are some possible reasons why women in developed countries live longer than men?
- biological differences - different chromosomes, hormones, immune system efficiency, metabolic rates
- lifestyle differences - men tend to drink and smoke more, have poor social support, more risky behaviour
- types of work/war - men tend to have more dangerous jobs and engage in war more often
what are our different types of immunity? what is immunosenescence?
- innate immunity - first line of defence, recognizes threat, rapid response
- adaptive immunity - comes in if innate immunity doesn’t work, is slower, able to target invaders the next time they’re introduced
-
immunosenescence - gradual deterioration of the immune system brought on by natural age advancement
- difficult to isolate the impact of aging on the function of the immune system
what happens to older adults as the immune system changes?
older adults are/have
- more susceptible to certain infections
- much higher risk of cancer
- benefit less from immunizations
- adaptive immunity is less efficient, tend to gert vaccinations early
- immune systems take longer to build up immune defenses
- more prone to serious consequences from illnesses
- immune system can begin attacking the body itself (autoimmunity)
what are acute vs. chronic diseases?
-
acute diseases - conditions that develop over a short period of time and cause a rapid change in health
- contracted less as we age because we build immunity and familiarity, but impact is more severe
-
chronic diseases - conditions that last a longer period of time (at least 3 months) and may be accompanied by residual functional impairment that necessitates long-term management
- believed to be a part of aging until the 1990
what are the most common chronic illness amongst those 65 years of age and older?
45% had arthritis, 43% had high blood pressure, and 18% had diabetes
what is multi-morbidity?
- having multiple chronic illnesses
- related to being a women and having low income
what population has the highest levels of chronic illness and why?
- aboriginal communities have higher levels of chronic illness
- may be due to food insecurity, high cost of food, and less nutrient dense food
- lack of culturally safe health care is a concern for aboriginal communities
what do we measure in order to assess level of health?
- we assess ability to perform activities of daily living (ADL) to assess level of health
- these measure provide functional assessment of health status by indicating degree of independence
how has the percentage of deaths by age changed?
- in 1921, the biggest proportion of deaths are in the first year of life (over 25%)
- in 1921, people are dying throughout adulthood (about 3-5% at every age group)
- in 1996, the age with the most deaths is about 70, but in 2011 it is about 85
- in the past, most deaths were due to acute illnesses but now they are due to chronic illness (cancer)
what lifestyle habits contribute to diseases?
- tabacco smoking
- physical inactivity
- unhealthy diet
- harmful alcohol use
- all contribute to cardiovascular disease, cancer, diabetes, chronic respiratory disease
what is diabetes?
- a chronic disease in which the body
- cannot produce insulin, or
- does not make enough insulin, or
- cannot properly use the insulin it produces (insulin insensitivity)
what is type 1 diabetes? what are some treatments?
- cannot produce insulin because cells have been attacked by own immune system
- generally develops in childhood and adolescents
- treated with insulin, diet planning and exercise
what is type 2 diabetes? what are some treatments?
- cannot properly use the insulin it produces (insulin insensitivity/insulin resistance) or does not make enough
- usually because cells are over-worked
- developed mostly in adults
- managed by physical activity, dietary planning, and medication and/or insulin if necessary
what are some complications and risks of high blood sugar?
- damage to and narrowing of arteries
- nerve damage
- chronic kidney disease - responsible for cleaning blood, there is a lack of blood flow to kidney
- lower limb amputation - people often don’t feel lower limbs, won’t notice injuries/infections
- diabetic retinopathy → blindness
- heart attack
- stroke
- erectile dysfunction
- death
what is the prevalence of diabetes by age? what people are more likely to develop diabetes?
- we are 30% more likely to get type 2 diabetes as we age
- aboriginal people are diagnosed at a younger age, and they experience greater severity, more complications from the disease and have poorer treatment outcomes
what is gestational diabetes?
- impacts 20% of pregnant women
- managed through diet, exercise, and medication
- greater risk of child developing type 2 diabetes
how can we prevent diabetes?
- maintain healthy weight with physical activity and healthy diet
- eat whole grains, lean meat, fruit and veggies, cut sugar
- screening over 40 years of age
- can catch prediabetes - higher than normal blood sugar
- be aware of relatives with Type 2 and of gestational diabetes
what are some barriers to self-care of diabetes?
- difficulty to adhere to treatment
- attitudes and beliefs about diabetes
- co-morbidities
- poor patient-practitioner communication and fit
- lack of social support
- financial restrictions
how do attitudes and beliefs act as a barrier to self-care of diabetes?
- some see insulin therapy as a sign of failure in managing diabetes
- think injections are restrictive, ineffective, may exacerbate
- think meds will worsen condition
- cultural beliefs - some think that you just need to stop having sugar
- also think that exercise is recommended to get rid of toxins, so they go to a sauna and sweat instead of exercise
how does cancer occur?
- cancer starts when cells change abnormally and cancer grows as cells multiple over and over
- most cancers start due to to gene changes that happen over a person’s lifetime
- not usually genetic
- more rarely, cancers start due to inherited faulty genes passed down in families
what are some environmental agents that contribute to the development of cancer?
- physical carcinogens (radiation), chemical carcinogens (asbestos), or biological carcinogens
- cancers become more prevalent with increasing age in adulthood because age is associated with greater cumulative exposure to harmful toxins (carcinogens)
- cancer can be caused by HPV, helicobacter pylori, Epstein‐Barr, and hepatitis B and C
- increased testosterone can lead to prostate cancer, estrogen in post-menopausal women increases likelihood of getting uterine cancer
how has detection of cancer and number of survivors changed?
- until the early 20th century, detection of cancer depended on gross signs and symptoms
- at that point, the cancer is already quite advanced and treatment is less likely to be successful
- 1982: 3 million cancer survivors living in the US (1.3%)
- 2016: 15.5 million cancer survivors in the US (4.7%) 3x the amount of people in 1982
- change is due to earlier detection, not necessarily more effective or different treatment
what was the social context surrounding cancer in the past?
- cancer associated with dread, fatalism, shame, silence, and stigma
- lack of control over treatment
- lack of support and acceptance
what is the prevalence of cancer and cancer deaths in Canada?
- 1 in 2 Canadians is expected to develop cancer during their lifetime
- 49% of men and 45% of women
- 1 in 4 Canadians is expected to die from cancer
- 28% of men and 24% of women
how has the age of people developing cancer changed?
- we are seeing more and more people in their 30s and 40s developing cancer
- raw numbers of cancer are increasing, but survival rates are also increasing
what are the most common forms of cancer and their 5 year survival rates?
- prostate (95%)
- lung (17%)
- breast (87%)
- colorectal (64%)
what are the different stages of cancer?
stage 0: no cancer, only abnormal cells with the potential to become cancer.
stage I: the cancer is small and only in one area (early-stage cancer)
stage II : the cancer is larger
stage III: the cancer is larger and has grown into nearby tissues or lymph nodes.
stage IV: the cancer has spread to other parts of your body (advanced or metastatic cancer)