5: Inflammation III Flashcards
Which process is triggered by hypoxia of tissue?
Acute inflammation
Why does hypoxia trigger acute inflammation?
Cell is damaged by enzymes released by pump failures
How many minutes does an MI patient have until their cardiac myocytes begin to die?
20 minutes
Where will MI changes first be seen?
ECG
At the start of hypoxic cell death, cells ___ and turn ___.
shrink
red
What, produced by neutrophils, triggers acute inflammation?
Cytokines
Which type of necrosis occurs in cardiac myocytes post-MI?
Which immune cell mops up the dead cells?
Coagulative necrosis (with ghost outlines)
Neutrophils
What may happen to the wall of the heart post-MI?
Rupture
Which cells replace neutrophils post-MI?
Macrophages
Does chronic inflammation occur post-MI?
Usually no
If there was suppuration you’d probably die
Is resolution common post-MI?
No
By definition the blood supply is poor and the injury probably lasted a long time
What occurs in the heart post-MI?
Organisation and scarring
Which cells lay down collagen in the heart post-MI?
Fibroblasts
What is an end stage disease which occurs post-MI?
Why?
Heart failure
Fibrous heart muscle is crap and doesn’t pump blood very well
