Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

midterms journal > 5 exca Physiology, Coagulation Pathways > Flashcards

5 exca Physiology, Coagulation Pathways Flashcards

1
Q

Cascade of events that leads to homeostasis

A

The coagulation pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Two paths of coagulation

A

Intrinsic and extrinsic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

T/F: the purpose of coagulation is to ultimately stabilize the platelet plug with a fibrin mesh

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Function of coagulation pathway is to keep _____ which is the blockage of a bleeding or hemorrhage

A

Homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

_____ homeostasis is an aggregation of platelets forming a plug at the damaged site of exposed endothelial cells

A

Primary homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

_____hemostasis includes the two main coagulation pathways, intrinsic and extrinsic, that meet up at a point to form the common pathway.

A

Secondary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The common pathway ultimately activates _________into fibrin

A

Fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Does fibrin subunits have an affinity for each other to combine into fibrin strands that bind the platelets together, stabilizing the platelet plug?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

The intrinsic pathway consists of factors

A

Factor I, II, IX, X, XI, and XII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name of factor 1

A

Fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Name of factor 2

A

Prothrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Name of factor 9

A

Christmas factor or plasma thromboplastin component (PTA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name of factor 10

A

Stuart prower factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Name of factor 11

A

Plasma thromboplastin antecedent (PTA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Name of factor 12

A

Hageman factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Factor 7 is called?

A

Stable factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Common pathway consists of

A

Factor I, II, V, VIII, X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

The factors circulate through the bloodstream as zymogens and are activated into

A

Serine proteases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

These serine proteases act as a catalyst to cleave the next zymogen into more serine proteases and ultimately activate

A

Fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Factors that has serine protease

A

Factor II, VII, IX, X, XI and XII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Factors has no serine proteases

A

Factor V, VIII, XIII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

The intrinsic pathway is activated through

A

Exposed endothelial collagen

23
Q

extrinsic pathway is activated through ________released by endothelial cells after external damage.

A

Tissue factor

24
Q

First factor that will activate in intrinsic pathway

A

Factor XII (inactivated serine protease)

25
Q

Factor XIIA acts as a catalyst to activate?

A

Factor IX into Factor XIA

26
Q

This factor is activated by either intrinsic or extrinsic pathway

A

Factor I

27
Q

Patient can actually clot well without factor?

A

Factor XII

28
Q

The intrinsic pathway is clinically measured as the?

A

Partial thromboplastin time (PTT)

29
Q

Once the damage to the vessel is done, the endothelial cells release _______ which goes on to activate factor VII to factor VIIa.

A

Tissue factor

30
Q

This is the point where both extrinsic and intrinsic pathways become one

A

Factor X

31
Q

The extrinsic pathway is clinically measured as the

A

Prothrombin time (PT)

32
Q

Common pathway begins at

A

Factor X

33
Q

the complex that cleaves factor X into factor Xa

A

Tenase

34
Q

Two forms of tenase

A

Extrinsic: factor VII, III and Ca2+
Intrinsic: cofactor factor VIII, XIA, phospholipid and Ca2+.

35
Q

Once activated to factor Xa, it goes on to activate factor II (prothrombin) into factor IIa (thrombin).

A

.

36
Q

factor Xa requires factor __ as a cofactor to cleave prothrombin into thrombin.

A

V

37
Q

Factor IIa (thrombin) goes on to activate fibrinogen into

A

Fibrin

38
Q

As thrombin acts as a procoagulant, it also acts as a __________ by activating __________to plasmin and stimulating the production of ________

A

Negative feedback, plasminogen, antithrombin

39
Q

acts directly on the fibrin mesh and breaks it down

A

Plasmin

40
Q

T/F: Thrombin decreases the production of thrombin from prothrombin and decreases the amount of activated factor X.

A

False: Antithrombin

41
Q

Protein C and S also act to prevent coagulation, mainly by inactivating factors

A

V and VIII

42
Q

Organs involved in coagulation cascade

A

Liver , vascular endothelium

43
Q

Lack of coagulation can lead to?

A

Hemorrhage

44
Q

Coagulopathy in liver disease is treated with

A

Fresh frozen plasma

45
Q

Hemophilia A is a deficiency in factor___ whereas; in hemophilia B is a deficiency in factor__?

A

Factor VIII, Factor IX

46
Q

Factor V Leiden is a genetic mutation more prevalent in people European descent. This defect causes a state of

A

Hypercoagulability

47
Q

Deficiencies in protein C and S also can lead to _________ states due to an inability to appropriately inhibit factors V and VIII respectively.

A

Hypercoagulable

48
Q

Example of factor inhibitor

A

Lupus anticoagulant

49
Q

Defeciency can lead to elevated PT and PTT. It can present as hemarthrosis

A

Vitamin K

50
Q

an anticoagulant used in hospital settings for deep venous thrombosis prophylaxis

A

Heparin

51
Q

T/F: Heparin binds and activates AT. AT goes on to inactivate thrombin and factor Xa.

A

True

52
Q

used for long-term therapy in patients with atrial fibrillation to prevent a thrombus from forming in the left atrium. It acts by inhibiting epoxide reductase.

A

Warfarin

53
Q

a critical component in coagulation factor production because it helps recycle Vitamin K. Without vitamin K more coagulation factors cannot be produced by the liver.

A

Epixode reductase

midterms journal (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions