#5: DM Complications

Question 1

Microvascular complications

Answer 1

Small vessel damage; MC T1DM

- diabetic opthalamology & diabetic nephropathy

Question 2

Macrovascular complications:

Answer 2

Arteriosclerosis dz of large vessels; MC T2DM

—> CAD; MI; stroke: peripheral vascular dz

Question 3

Microvascular complication are directly related to:

Answer 3

• glycemic control

Question 4

Macrovascular complication are directly related to:

Answer 4

• the usual RF’s (lipids, HTN) & glycemic control

Question 5

This enhances the risk for all complications extensively

Answer 5

Cigarette smoking

Question 6

Major cause of death: T1DM

Answer 6

Proliferative retinopathy and ESRD

Question 7

Major cause of death: T2DM

Answer 7

MI and CVA

Question 8

First line tx of dislipidemia in DM

Answer 8

Statins @ moderate to high intensity dose
Simvastatin (zocor)
Atorvastatin (lipitor)
Rosuvastatin (crestor)

Question 9

Lipoprotein abnormalities in T1DM

Answer 9

Slight elevation LDL and TG

Question 10

Lipoprotein abnormalities in T2DM

Answer 10

Increase in TG (300-400 mg/dL)
Decrease in HDL (<30 mg/dL)
More atherogenic LDL

Question 11

Major ASCVD risk factors-

Answer 11

1- fam hx
2- low hdl (<40)
3- HT
4- smoking

Question 12

DM but no other major risk factors and/or age <40

Answer 12

LDL-C: <100 mg/dL

TG: <150 mg/dL

Question 13

DM with +1 major ascvd risk factor or pre-existing CVD:

Answer 13

LDL-C: <70 mg/dL

TG: <150 mg/dL

Question 14

Microalbuminuria lab numbers

Answer 14

30-300 mcg PRO/day