5 Autism Spectrum Disorder Flashcards

1
Q

What are 3 symptoms of ASD according to the DSM?

A

Deficits in social communication and interactions / restricted and repetitive patterns of behaviour / impaired social occupational functioning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are 3 low social communication deficits is ASD?

A

Difficulty adjusting behaviour / poorly integrated / no back and forth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are 3 medium social communication deficits is ASD?

A

Reduced sharing of emotions / abnormal eye contact / abnormal body language

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are 3 high social communication deficits is ASD?

A

No response to social interaction / non-verbal / lack of expression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are 3 motor stereotyped behaviours in ASD?

A

Lining up toys / flipping objects / idiosyncratic phrases / echolalia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is hypo reactivity in ASD?

A

Being indifferent to pain and temperature

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is hyper reactivity in ASD?

A

Excessive smelling or touching / visual fascination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is syndromic ASD?

A

Autism associated with a genetic disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What did Spezio’s research into ASD patients find?

A

There are differences in eye movements / ASD focus on the mouth and nose / controls focus on the eyes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are 5 possible environmental risk factors for developing ASD?

A

Maternal infection / preterm birth / exposure to valporic acid / history of autoimmune disease / short pregnancy intervals / advanced parental age / obstetric complications

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is considered an advanced parental age, as a risk factor for ASD?

A

Maternal 40+ / paternal 50+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is considered an obstetric complication, as a risk factor for ASD?

A

Weight gain / hypertension / metabolic condition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What causes fatal valporate syndrome?

A

Anti-epileptic drugs / teratogens / increased acetylation of histones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What 3 symptoms of ASD can be seen via neuropathology?

A

Social behaviour / language and communication deficits / repetitive and stereotyped behaviour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is a difference in brain volume of ASD patients?

A

5-10% enlargement and increased white matter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are three differences in columnar structure of ASD patients?

A

Columnar structure is reduced / less space for dendritic bundles / less space for axonal fascicles / decreased dendritic arborisation / increased neuronal density

17
Q

What is different about the cerebellum of ASD patients?

A

It is enlarged / the vermis is smaller

18
Q

What is different about the amygdala of ASD patients?

A

13-16% enlargement

19
Q

What % heritability is ASD?

A

80%

20
Q

What is upregulated to potentially cause ASD?

A

Microglia

21
Q

What is downregulated to potentially cause ASD?

A

Neuronal firing

22
Q

Give three examples of de novo CNV’s and SNV’s?

A

CHD8, SYNGAP1, SCN2A

23
Q

Give an example of a copy number variation?

A

MECP2

24
Q

What is the male:female ratio of developing ASD?

A

4:1