5/24 Lecture E3 Flashcards
What is weight determined by?
The body’s energy balance; combination of heredity (30-50%) and environmental influences
What is involved in the control of weight?
several peptide hormones and regulatory pathways that control sort and long-term appetite
What do short term regulators of appetite do?
make one feel hungry or satiated to begin or end eating.
What do short term regulators of appetite include?
peptides ghrelin, peptide YY, cholecystokinin, and amylin
What is Ghrelin?
A substance secreted from parietal cells in the fundus of an empty stomach that produces the sensation of hunger.
What gland does Ghrelin stimulate?
stimulates the hypothalamus to secrete growth hormone releasing hormone
What is Peptide YY? (PYY)
a substance secreted by enteroendocrine cells of the ileum and colon that can sense that food has arrived in the stomach, in order to signal satiety and terminate eating.
How much PYY is secreted?
the amount is proportional to the number of calories consumed
What is Cholecystokinin (CCK)
a substance secreted by enteroendocrine cells in the duodenum and jejunum that stimulates the secretion of bile and pancreatic enzymes.
What does CCK do?
stimulates brain and sensory fibers of vagus nerve, suppressing appetite.
What is Amylin?
A substance secreted from beta cells of the pancreas that produces satiety and inhibits stomach activity.
What substances act as a signal to stop eating?
Peptide YY, Cholecystokinin and Amylin
What substance produces the sensation of hunger?
Ghrelin
What do long-term regulators of appetite do?
Govern caloric intake and energy expenditure over periods of weeks to years.
What peptides inform the brain of how much adipose the body has?
Leptin and Insulin
What secretes Leptin?
adipocytes throughout the body
What does leptin do?
informs the brain on how much fat it has.
What secretes insulin?
pancreatic beta cells
What does insulin stimulate?
glucose and amino acid uptake
What does insulin promote?
glycogen and fat synthesis
Which has a greater effect on appetite: insulin or leptin
leptin
What has receptors for all short and long term chemical signals?
The Arcuate nucleus of the hypothalamus
What are the two substances secreted by the arcuate nucleus of the hypothalamus that affect appectite?
Neuropeptide Y and melanocortin
What is neuropeptide Y?
a potent appetite stimulant
what is melanocortin?
an eating inhibitor
What stimulates neuropeptide Y?
Gherlin
What inhibits neuropeptide Y?
insulin, PPY, and leptin
What stimulates Melanocortin?
Leptin
What does melanocortin inhibit?
the secretion of appetite stimulants (endocannabinoids)
What partly stimulates hunger?
gastric peristalsis
Does gastric peristalsis affect the amount of food consumed?
NO. Its the PYY and CCK that shut off food intake.
What are the lasting effects of satiety due to?
nutrients absorbed into the blood.
What do neurotransmitters do?
stimulate the desire for different types of food.
What food type does the neurotransmitter norepinephrine stimulate the desire for?
carbohydrates
What food type does the neurotransmitter galanin stimulate the desire for?
fats
What food type does the neurotransmitter endorphins stimulate the desire for?
protein
What is one calorie?
the amount of heat required to raise temperature of 1 g of water 1 degree C.
What is one Calorie (in dietetics)
1,000 calories, or 1 kcal in physiology
What is a calorie measure?
the capacity to do biological work.
How many kcal/g do carbs and proteins yield?
about 4 kcal/g
why are sugar and alcohol considered “empty” calories?
they provide few nutrients and suppress appetite
how many kcal/g do fats yield?
about 9 kcal/g
what is a nutrient?
any ingested chemical used for growth repair, or maintenance of the body.
What are the 6 classes of nutrients
water, carbs, lipids, proteins, vitamins, minerals
What are considered macronutrients?
nutrients that must be consume in relatively large quantities: water, carbs, lipids, proteins
What are considered micronutrients?
nutrients that are only needed in small quantities: vitamins and minerals
What are DRIs?
dietary reference intakes: RDAs (recommended dietary allowances) and AIs (adequate intake)
What are essential nutrients
nutrients that cannot be synthesized in the body: minerals, most vitamins, eight amino acids, and 1-3 of the fatty acids
A well-nourished adult body has what amount of carbs?
440 g:
325 g of muscle glycogen
90-100 g of liver glycogen
15-20 g of blood glucose
what are the functions of sugars?
1) structural components of other molecules including nucleic acids, glycoproteins, glycolipids, ATP, and related nucleotides (GTP, cAMP)
2) most serve as fuel
Why does most sugar serve as fuel for the body?
because they are easily oxidized source of chemical energy
What body components depend solely on carbohydrates?
Neurons and erythrocytes
What is hypoglycemia?
deficiency of blood glucose
What does hypoglycemia cause?
nervous system disturbances such as weakness and dizziness
How is plasma glucose concentration carefully regulated?
interplay of insulin and glucagon; balance between glycogen and free glucose
how does carb intake influence metabolism of other nutrients?
fats used as fuel when glucose and glycogen levels are low, and excess carbs are converted to fat.
What nutrient is required in greater amounts than any other nutrient?
carbohydrates
What is the RDA for carbs?
130 g
how many carbs does the brain consumer daily?
120 g of glucose per day
What is the average consumption of sugar and corn syrup per year?
60 lb of sugar and 46 lb of corn syrup
Dietary carbs come in what three principal forms?
glucose, galactose, and fructose
where do dietary carbs mainly come from?
mainly from digestion of starch and disaccharides.
What organs convert galactose and fructose to glucose?
small intestine and liver
What is a normal blood sugar (glucose) concentration?
70-110 mg/dL
What are the disaccharides?
sucrose (table sugar), maltose, lactose
What are the polysaccharides (complex carbs)?
starch, glycogen, and cellulose
is cellulose a nutrient?
no, because it is not digested, but is important as a dietary fiber.
where do nearly all dietary carbs come from?
plants
Where does sucrose come from?
Sucrose is refined from sugarcane and sugar beets
where does fructose come from?
Fructose is present in fruits and corn syrup
Where does maltose come from?
Maltose is present in some cereal grains
Where does Lactose come from?
Lactose is found in cow’s milk.
What is dietary fiber?
All fibrous material of plant and animal origin that resists digestion: cellulose, pectin, gums, and lignins
What is the RDA for fiber?
25 g/day for females, 38 g/day for males
Where is water soluble fiber found?
In oats, beans, peas, brown rice, and fruits
What role does water-soluble fiber play in the body?
decreases blood cholesterol and LDL levels
What are some types of water-insoluble fiber?
cellulose, hemicellulose, lignin
Do water-insoluble fibers have an effect no cholesterol and LDL levels?
no
What does water-insoluble fiber do?
absorbs water in intestines
softens stool and increases its bulk
stretches the colon
stimulates peristalsis (quickens passage of feces
What can excessive intake of water-insoluble fiber do?
interfere with absorption of some elements such as iron, calcium, magnesium, phosphorous, and others
What is the average body fat percentage for females and males?
females: 25%
males: 15%
A well-nourished adult meets 80-90% of resting energy needs from what?
fat
which is superior for energy storage and why?
fat is superior to carbs because:
1) carbs are hydrophilic, absorbs water, and expands, occupying more space in tissue, whereas fat is hydrophobic and is more compact energy storage
2) fat contains over twice as much energy: 9 kcal/g for fat; 4 kcal/g for carbs
What are the glucose sparing effects of fat?
Glucose is spared for consumption by cells that cannot use fat, like neurons
What are the protein sparing effects of fat?
Protein is spared as fuel as long as there is enough fat.
What are the fat soluble vitamins that are absorbed with dietary fat?
A, D, E, K
How much fat is needed per day in order to absorb the necessary amount of fat soluble vitamins?
20 g/day
What other diverse functions does fat have besides an energy source?
1) structural: phospholipids and cholesterol (components of plasma membranes and myelin
2) chemical precursors:
3) important protective and insulating functions
What are the chemical precursors that fat assists with?
cholesterol (precursor of steroids, bile salts, vitamin D
thromboplastin (an essential blood-clotting factor; a lipoprotein)
fatty acids (arachidonic acid and linoleic acid: precursors for prostaglandins and other eicosanoids
What are the daily fat requirements?
less than 35% of daily calorie intake:
1) less than 10% of fat as saturated
2) limit saturated fat and cholesterol
how much fat does the typical American get?
40-50%
Where are most fatty acids found?
they are synthesized by the body
Where are saturated fats from?
Animal origins (meat, egg yolks, dairy products) some in coconut and palm oils
Where are unsaturated fats from?
nuts, seeds, and most vegetable oils