45 1&2, 48 1-4, 49 2 Flashcards
endocrine system
chemical signalling by hormones: 1 of 2 communication systems
nervous system
neurons that transmit signals along dedicated pathways:
1 of 2 communication systems
4 types of cell signalling
endocrine, paracrine, autocrine, synaptic and neuroendocrine signalling
endocrine signalling
- reach target cells via blood stream (hemolymph)
- triggers response in target cells anywhere in the body
- maintains homeostasis, mediates response to environmental stimuli, regulates growth and development
local regulators
act over short distances and reach target cells solely by diffusion ex.cytokines either paracrine and autocrine
paracrine signalling
local regulators trigger a response in neighboring cells
autocrine signalling
local regulators trigger a response in the cells that diffuse them
synaptic signalling
neurons form specialized junctions called synapses with target cells ex. muscle cells and other neurons
neurotransmitters
produced at synapses, molecules secreted that diffuse a short distance to bind to receptors at target cells ex. sensation, memory, cognition, movement
neuroendocrine signalling
neurohormones secreted by specialized neurons that diffuse from nerve cell ending and enter the bloodstream hitting target cells anywhere in the body
pheromones
chemicals released into the external environment for communication
endocrine cells can be found in..
endocrine glands and dispersed in organs with other functions
endocrine glands
endocrine cells grouped in ductless organs ex. thyroid and parathyroid
exocrine glands
carry secreted substances on the surface of the body ex.saliva
list of endocrine glands
hypothalamus, pineal gland, pituitary gland, thyroid gland, parathyroid glands, adrenal glands, pancreas, ovaries, testes
what are lipid soluble hormones + examples
diffuse across membranes of endocrine cells and outside cells they bind to transport proteins steroids: cortisol+thyroxine
what are water soluble hormones+examples
secreted by exocytosis polypeptides: insulin+epinephrine
signal transduction
the series of changes that converts the extra-cellular chemical signal to a specific intracellular response
epinephrine
due to short-term stressful situation secreted by adrenal glands also called adrenaline; causes liver to release glucose
many hormones elicit more than one
response
growth factors
stimulate cell proliferation and differentiation
nitric oxide
neurotransmitter and local regulator
prostaglandins
help sperms reach egg, help labor, regulate platelet aggregation, promotes fever and inflammation, and help maintain stomach lining
simple endocrine pathway
endocrine cells respond directly to an internal or environmental stimulus by secreting a particular hormone
simple neuroendocrine pathway
stimulus is received by a sensory neuron which stimulates a neurosecretory cell which secretes a hormone into the bloodstream
negative feedback
a loop in which the response reduces the initial stimulus
positive feedback
reinforces a stimulus, leading to an even greater response
insulin
released when blood sugar is high and triggers cells to uptake glucose: made by beta cells
glucagon
released when blood sugar is low and triggers release of glucose into the blood from energy stores such as liver glycogen:made by alpha cells
diabetes mellitus
deficiency of insulin (type 1) or decreased response to insulin (type 2)