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Pharmacology > 4.3 - Eicosanoids > Flashcards

4.3 - Eicosanoids Flashcards

1
Q

Eicosanoids

A
  • Biosynthesis

* Effects

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2
Q

Biosynthesis

A

Sources

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3
Q

Sources

A

• Phospholipids (major)
• Phosphatidyl inositol (alternative)
⬇️⬇️⬇️
Arachidonic Acid

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4
Q

Phospholipids ➡️ Arachidonic Acid

A

Phospholipase A2

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5
Q

Phosphatidyl inositol ➡️ Arachidonic Acid

A

Phospholipase C

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6
Q 
Arachidonic Acid
⬇️
– Prostaglandins
– Thronboxanes
– Prostacyclin (PGI2)
A

Cycolooxygenase (COX)

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7
Q

Arachidonic Acid
⬇️
Leukotrienes

A

5-Lipoxygenase (LOX)

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8
Q

– 5, 8, 11, 14-eicosatetraenoic acid

– 20C; 4 double bond

A

Arachidonic Acid

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9
Q

Cyclooxygenase

A
  • Prostaglandins
  • Thromboxanes
  • Prostacyclin (PGI2)
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11
Q

– Cytoprotection
– Vasodilation
– Pain & Inflammation

A

Prostaglandins

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12
Q

– Platelet aggregation

– Vasoconstriction

A

Thromboxanes

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13
Q

5-Lipooxygenase

A

Leukotrienes

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14
Q

Leukotrienes

A
  • LTB4

* LTC4/ LTD4

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15
Q

– Chemotactic factor

– Induces the movement of immune cells

A

LTB4

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16
Q

– SRSAs

– Slow-reacting substance of Anaphylaxis

A

LTC4/ LTD4

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17
Q

Effects

A
  • Blood vessels
  • Bronchi
  • GIT
  • Platelets
  • Uterus
  • Reduction of intraocular pressure
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18
Q

Blood vessels

A
  • Vasodilation

* Vasoconstriction

19
Q

Vasodilation

A
  • PGI2 (Prostacyclin)

* PGE series

20
Q

Vasoconstriction

A
  • TXA2

* PGF2a

21
Q

Bronchi

A
  • Bronchodilation

* Bronchoconstriction

22
Q

Bronchodilation

A
  • PGI2

* PGE series

23
Q

Bronchoconstriction

A
  • LTC4

* LTD4

24
Q

GIT

A

Cytoprotection

– PGE1

25
Q

Platelets

A
  • Platelet aggregation

* Inhibition of platelet aggregation

26
Q

Platelet aggregation

A

TXA2

27
Q

✖️ Platelet Aggregation

A
  • PGI2

* PGE1

28
Q

Uterus
— PGE series
— PGF2a

A
  • Contraction

* Dysmenorrhea

29
Q

Reduction of Intraocular Pressure

A

– PGF2a

– PGE series

30
Q

Drugs

A
  • Epoprosterenol
  • Misoprostol
  • Alprostadil
  • Dinoprostone
  • Latanoprost
  • Carboprost tromethamine
31
Q

PGI2

A

Epoprosterenol

32
Q

PGE1

A
  • Misoprostol

* Alprostadil

33
Q

PGE2

A

Dinoprostone

34
Q

PGF2a

A
  • Latanoprost

* Carboprost tromethamine

35
Q

– Mgt of primary pulmonary HTN (vasodilator)
** Silfenafil — PDE5 inhibitor
(Revatio®)

A

Epoprosterenol

36
Q 
– Use:
 - Cytoprotectant
 - Mgt OF PUD — NSAID induced
– S/E: 
 - abortion
A

Misoprostol

37
Q

– Mgt of erectile dysfunction

– Maintain the patency of the ductus arteriosus

A

Alprostadil

38
Q

– cervical ripening

– abortifacient (vaginal suppository)

A

Dinoprostone

39
Q

– Mgt of Galucoma

- Xalatan®

A

Latanoprost

40
Q

– Abortifacient

A

Carboprost tromethamine

41
Q

– Vasodilation

– Inhibits platelet aggregation

A

Prostacyclin (PGI2)

Pharmacology (21 decks)

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