1.3 - Drug-Response Relationship Flashcards
1
Q
Graded - Dose Response Relationship
A
- Plot
- Parameters
- Applications
2
Q
Degree of Response vs. Dose or Log Dose
A
Plot
3
Q
Parameters
A
- Efficacy
- Ceiling Dose
- Potency
- Slope
4
Q
The maximum achievable repsonse
A
Efficacy (E)
5
Q
The smallest dose that produces the maximum response
A
Ceiling Dose (Dc)
6
Q
Dose required to achieve 50% of the maximum response (⬇️ value = ⬆️ potency)
A
Potency
7
Q
Degree of change in response with a change in dose
A
Slope
8
Q
– Drastic
– Start low, go slow
A
Steep
9
Q
Can be adjusted
A
Not Steep
10
Q
Applications
A
- Efficacy vs Potency
- Full Agonist, Partial Agonist & Inverse Agonist
- Competitive Antagonism
- Non-Competitive Antagonism
12
Q
Quantal - Dose Response Relationship
A
- Plot
* Parameters
13
Q
Cumulative # of pt vs Log Dose
A
Plot
14
Q
Parameters
A
- ED50
- TD50
- Therapeutic Index
- Margin of Safety
15
Q
– Median EFFECTIVE dose
– Effective dose in 50% of the given population
A
ED50
16
Q
– Median TOXIC dose
– Toxic dose in 50% of the given population
A
TD50
17
Q
– Measure of the RELATIVE SAFETY of drugs
A
Therapeutic Index (I)
