1.3 - Drug-Response Relationship Flashcards

1
Q

Graded - Dose Response Relationship

A
  • Plot
  • Parameters
  • Applications
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2
Q

Degree of Response vs. Dose or Log Dose

A

Plot

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3
Q

Parameters

A
  • Efficacy
  • Ceiling Dose
  • Potency
  • Slope
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4
Q

The maximum achievable repsonse

A

Efficacy (E)

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5
Q

The smallest dose that produces the maximum response

A

Ceiling Dose (Dc)

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6
Q

Dose required to achieve 50% of the maximum response (⬇️ value = ⬆️ potency)

A

Potency

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7
Q

Degree of change in response with a change in dose

A

Slope

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8
Q

– Drastic

– Start low, go slow

A

Steep

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9
Q

Can be adjusted

A

Not Steep

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10
Q

Applications

A
  • Efficacy vs Potency
  • Full Agonist, Partial Agonist & Inverse Agonist
  • Competitive Antagonism
  • Non-Competitive Antagonism
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12
Q

Quantal - Dose Response Relationship

A
  • Plot

* Parameters

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13
Q

Cumulative # of pt vs Log Dose

A

Plot

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14
Q

Parameters

A
  • ED50
  • TD50
  • Therapeutic Index
  • Margin of Safety
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15
Q

– Median EFFECTIVE dose

– Effective dose in 50% of the given population

A

ED50

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16
Q

– Median TOXIC dose

– Toxic dose in 50% of the given population

A

TD50

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17
Q

– Measure of the RELATIVE SAFETY of drugs

A

Therapeutic Index (I)