42A Adult Seizure Disorder Flashcards

1
Q

Note incidence of seizures peaks in:

A

children and in the elderly

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2
Q

What causes adult-onset seizures?

A
CV disease
trauma
tumors
infections
cerebral degeneration
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3
Q

Partial seizures are:

A

focal onset seizures that emanate from a specific cortical head region

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4
Q

Generalized seizures are:

A

non-focal and thought to emanate from the brainstem structures –> spread to both hemispheres at the same time

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5
Q

Types of partial seizures?

A
  1. simple (consciousness conserved, nml EEG)

2. complex (LOC, abn EEG)

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6
Q

Partial seizures may progress to:

A

secondarily generalized (LOC + bil cerebral involvement)

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7
Q

Complex partial seizures typically emanate from:

A

temporal or frontal lobes.

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8
Q

Behavioral features associated with complex partial seizures?

A
  1. blank stare
  2. oral/ipsalat hand automatisms
  3. contralat dystonic posturing
  4. amnesia of event
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9
Q

How are absent seizures characterized?

A
  1. 10-20s LOC
  2. staring w/ subtle eyelid flutter
  3. absence of post-ical confusion
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10
Q

EEG in absent seizures?

A

generalized 3Hz spike, wave discharges

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11
Q

Typical presentation of tonic-clonic seizure?

A
  • cry, LOC
  • musc rigidity
  • possibility of falling, tongue biting
  • rhythmic jerking
  • incontinence
  • post-ictal conf/sleep
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12
Q

Typical presentation of myoclonic seizure?

A
  • brief, shock-like musc contr (head/UE)
  • bil symm
  • consciousness preserved
  • ppt by awakening or falling asleep
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13
Q

Myoclonic seizure may progress to…

A

tonic-clonic

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14
Q

Typical presentation of atonic seizure?

A
  • impaired consciousness
  • loss of musc tone
  • head drop
  • fall
  • brief duration
  • injury common
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15
Q

EEG abn seen in seizures?

A

sharp and slow wave discharge w/ phase reversal

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16
Q

Pathophys of seizures (GABA)?

A

GABA activates GABA-a receptors, which mediate fast synaptic inhibition (IPSP) by allowing rapid influx of Cl- (=hyperpol)

17
Q

Pathophys of seizures (glutamate)?

A

glutamate activates AMPA, Kainate, NMDA –> fast synaptic excitation via Na/Ca influx

18
Q

A seizure results when:

A

excitation significantly exceeds inhibition

19
Q

What is generalized convulsive status epilecpticus?

A

continuous, generalized, convulsive seizure lasting more than 5 min OR 2+ seizures w/o full recovery of consciousness