410- Exam 3 Material

Question 1

Beta 1

Answer 1

• increased HR, ventricular contractility, and AV condction when stimulated by epinephrine or norepinephrine
• INC HR
• Located mainly in inner ear

Question 2

Beta 2

Answer 2

-Causes coronary, lung, and skeletal muscle vasculature to dilate when stimulated by epinephrine or norepinephrine
-inc bronchodilaton as well
Located on vascular and bronchial smooth muscle

Question 3

Alpha 1 receptors

Answer 3

• causes vasoconstriction when stimulated by epinephrine or norepinephrine
• Located on peripheral vascular smooth muscle (arterioles and veins)

Question 4

Alpha 2 receptors

Answer 4

• may cause sedation, and vasodilation or vasoconstriction when stimulated, depending on tissue/ organ
• presynaptic
• works on a negative feedback sys which inhibits sympathetic outflow

Question 5

Beta Blockers

Answer 5

• Slows HR
• Dec HR, ventricular contractility and electrical conduction velocity (beta 1 receptors)
• Bl vessel response depends on the organs being supplied
• generic names end in olol
• inhibit interaction btwn catecholamines and beta 1 and beta 2 receptors

Question 6

Alpha 1 receptor Blockers

Answer 6

• reduce vasoconstriction
• usually end in -azosin
• same type action as beta blockers, except they block alpha receptors

Question 7

Nitrates and Nitroglycerine

Answer 7

• Primary action: relax vascular smooth muscle in arteries and veins, causing dilation
• dec venous constriction, dec venous return, dec arterial constriction
  thus myocardial oxygen demand and in o2 delivery to myocardium

Question 8

Nitrates

Answer 8

• tolerance may develop

Question 9

Side Effects of Nitrates

Answer 9

• hypotension
• Headache
• Reflex tachycardia
• tolerance

Question 10

calcium channel blockers

Answer 10

• medications that relax blood vessels and increase the supply of blood and oxygen to the heart while also reducing the heart’s workload
• smooth muscle: block calcium channels in vascular smooth muscles, dec vasoconstriction, promoting arterial/venous vasodilation
• similar to nitrates, also dec mvo2 and inc o2 delivery-
• meds end in -ipine

Question 11

Fibric Acid Derivatives

Answer 11

Inc Lipoprotein lipase activity which catabolizes VLDL

• Lowers triglyceride levels in the blood