4.1 Intro to Liver disease Flashcards

1
Q

What do hepatocytes synthesis?

A
Albumin 
Lipoproteins 
Coagulation factors (2,7,9,10) 
Glycogen 
Urea 
Bile salts 
Cholesterol
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2
Q

What do hepatocytes excrete?

A
Bilirubin 
Bile salts 
Ammonia 
Alcohol 
Drugs 
Toxins
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3
Q

What are the symptoms of acute hepatitis (hepatocellular necrosis)

A
Anorexia 
Lethargy 
Jaundice 
Biliruninuria
Tender liver 
ALT > 10x
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4
Q

Symptoms of cholestasis

A
Jaundice 
Biliruninuria 
Pale stools 
Malabrosption 
Pruritis
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5
Q

What are the symptoms of liver failure with portal hypertension?

A

Ascites
Dilated abdominal veins
Muscle wasting
Fullness in left flank (splenomegaly)

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6
Q

What are the features of compensated cirrhosis?

A
Jaundice 
Ascites 
Hepatic encephalopathy 
Impaired protein synthesis (coagulopathy) 
Catabolism: muscle wasting
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7
Q

What LFTs indicate cholestasis?

A

ALP > 2x and ALP more than 3x ALT, raised GGT

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8
Q

What LFTs indicate hepatocellular damage?

A

ALT > 2x and ALT more than 3x ALP

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9
Q

What LFTs will you see in hepatitis?

A

ALT >2-5, GGT raised

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10
Q

What LFTs will you see in cirrhosis

A

Low albumin, prolonged PT, low platelets

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