4.1 Communicable Diseases Flashcards

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1
Q

what is a pathogen

A

A microorganism which causes disease to a host

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2
Q

what is a communicable disease

A

Diseases caused by infective organisms known as pathogens

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3
Q

what is bacteria

A

Prokaryotes which are capable of rapid reproduction. Bacteria can cause direct damage to cells or release toxic substances.

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4
Q

3 types of bacterial diseases & relevant information

A

Tuberculosis: Is cause by mycobacterium tuberculosis which often infects the lungs, killing cells & tissues

Bacterial Meningitis: Is caused by Neisseria Meningitidis which infects the meninges (membranes that surround the brain and spinal cord) leading to the brain & nerves

Ring Rot: This is a plant disease which causes decay of the vascular tissues in potatoes and tomatoes.

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5
Q

which 2 ways can bacteria be classified

A

Shape: Bacteria can have the following shapes: Rod shaped (bacilli), spherical (cocci), common shaped (vibrio), spiralled (spirilla), Corkscrew (Spirochaetes)

Cell Wall: Gram positive bacteria appear blue purple after gram staining e.g. MRSA. Gram Negative Bacteria appear red under a microscope after gram staining e.g. E-coli. This is useful as the type of cell wall affects how bacteria responds to antibiotics.

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6
Q

what are protist

A

eukaryotic cells that are single celled organism and multi-cellular organisms

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7
Q

what do protist mainly require

A

vectors

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8
Q

example of protist

A

malaria

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9
Q

Fungi

A

eukaryotes but can be unicellular or multicellular

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10
Q

how do Fungi work/function

A

They are saprophytes (sprays enzymes on dead matter to digest and absorb the nutrients). When fungi affect plants, they often infect the leaves preventing photosynthesis. Fungi produce many millions of spores that rapidly infect other organisms.

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11
Q

Virus definition

A

Not considered living by many scientists as they are non-cellular and only active when inside a host cell. Viruses consist of nucleic acids (DNA or RNA) surrounded by a protein coat. Despite their simplicity they are responsible for a wide range of common and life-threatening diseases.

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12
Q

3 viral diseases and relevant information

A

HIV/AIDS: caused by human immunodeficiency virus. It is a retrovirus (RNA is used to make DNA) and can splice its genes into the host’s chromosomes. The virus attacks & destroys T-helper cells thus compromising the host’s immune system possibly to AIDS

Influenza: occurs in several animal groups including birds & other mammals. An avian influenzas outbreak occurred in China in 2013.

Tobacco Mosaic Virus (TMV): A plant virus which cause ‘mosaic’ mottling. It does not kill the plant but can result in stunted growth and so reduced yield

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13
Q

what is direct transmission

A

Involves transmission when there is contact between infected person and suspectable person

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14
Q

4 examples of direct transmission

A
  1. Faecal-Oral: Contaminated food or water e.g. Cholera
  2. Droplet: Coughing or sneezing e.g. TB or influenzas
  3. Spores: Some bacteria and fungi produce reproductive spores which can travel through air e.g. Tetanus
  4. Invasion: Bacteria which use their flagellum and pili to swim towards the host and enter wounds in the plant
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15
Q

indirect transmission

A

This involves transmission of a vector which is another organism used by the pathogen to infect the host

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16
Q

6 factors effecting transmission in animals

A

Overcrowded living and working conditions

Poor nutrition

A compromised immune system, including having HIV / AIDS or needing immunosuppressive drugs off the transport surgery.

Climate change -This can introduce new vectors and new diseases, for example, increase temperature, promote the spread of malaria as the vector mosquito species is able to survive over a wider area.

Culture. An infrastructure- In many countries, traditional medical practises can increase transmission.

Socioeconomic factors- A lack of trained health workers, an insufficient public warning when there is an outbreak of disease can also affect transmission rate.

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17
Q

how does direct transmission occur in plants

A

Involves physical contact between plant and any part of diseased plant

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18
Q

example of indirect transmission

A

Soil contamination through infected plants, living pathogens or reproductive spores from protocosista or fungi in the soil. This can infect the next crop. Examples are black sigatoka spores, ring rot bacteria, spores.

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19
Q

4 examples of vectors transmitting diseases to plants

A

Wind- Bacteria, viruses, and fungal spores may be carried in the wind.

Water- Spores swim in the surface film of water on leaves; Raindrop splashes carry pathogens and spores. Examples are spores of P. infestans (potato blight) which swim over films of water on the leaves.

Animals- Insects and birds carry pathogens and spores from one plant to another as they feed. Insects such as aphids inoculate pathogens directly into plant tissue.

Human- Pathogens and sports are transmitted by hands, closing formats, farming practises and by transporting plants and crops around the world. For example, TMV survives for years in tobacco products, Ring Rot survives on farm machinery.

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20
Q

factors affecting plant disease transmission

A

Planting varieties of crops that are susceptible to disease.

Overcrowding increases the likelihood of contact.

Poor mineral nutrition reduces resistance of plants.

Damp, warm conditions increase the survival and spread of pathogens and spores.

Climate change- increased rainfall and went promote the spread of diseases; Changing conditions allow animal vectors to spread to new areas while drier conditions may reduce the spread of the disease.

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21
Q

5 physical defences in plants

A

Cellulose cell wall: Acts as a physical barrier as well as containing a variety of chemical defences that can be activated when a pathogen is detected.

Lignin thickening of cell walls: Lignin is waterproof and almost completely indigestible.

Waxy cuticles: These prevent water collecting on the cell surface is since pathogens collect in water, they need water to survive. The absence of water is a passive defence.

Bark: Most bark contains a variety of chemical defences that work against pathogenic organisms.

Callose: callose is a large polysaccharide that is deposited in the sieve tubes at the end of a growing season. It is deposited around the seed plates and blocks the flow. In the sieve tube, this can prevent a pathogen spreading around the plant. In addition, after an initial attack, callose is synthesised and deposited between the cell walls and the cell membrane in cell next to the infected cell. These act as barriers and prevent the passage and from entering the plant cells around the site of infection.

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22
Q

3 chemical defences in plants

A

Phenols: Have antibiotic and antifungal properties.

Alkaloids Better to prevent grazing and interferes with enzyme action

Hydrolytic enzymes: Breakdown fungal and bacterial cell walls. These chemicals can act on the pathogen and the vector (if present) or both. They are found in spaces between cells.

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23
Q

what is necrosis

A

The deliberate cell suicides.

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24
Q

how does necrosis happen

A

A few souls are sacrificed to save the rest of the plant. By killing cells surrounding the infection, the plant could limit the pathogens, access to water and nutrients and therefore stop it spreading further around the plant. Necrosis is brought about by intracellular enzymes that are activated by injury. These enzymes destroy damaged cells and produce brown spots on leaves or die back.

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25
Q

how is skin a physical defence

A

Skin cells are produced at the base of the epidermis. As they migrate towards the skin surface, they become keratinized, which serves as a barrier to pathogens. The skin also produces sebum, which is an oily substance to inhibit the growth of pathogens.

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26
Q

how are mucous membranes a physical defence

A

Many of the body tracks, including the Airways of the gas exchange system, are lined by mucous membranes that secrete sticky mucus. This drops microorganisms an contains lysosomes which destroy bacterial and fungal cell walls. Mucus also contains phagocytes which remove remaining pathogens.

27
Q

How are fluids a physical defence

A

Lysosomes in tears and urine and the acid in the stomach also help prevent. Pathogens from getting into our body.

28
Q

how is blood clotting a physical defense

A

Any damage to the skin. Offers a potential entry point for pathogens. Blood clotting is important for preventing excessive blood loss. And the invasion of pathogens it is in central blood does not clot inside blood vessels. Damage to the wall of the blood vessels start the clotting process played. Let’s bind to the exposed collagen at the site of damage and release clotting factors. These activate a complex custard of reactions which results in a soluble protein in the blood plasma converting to soluble fibrin. The febrile forms a fibrous mesh which traps red blood cells and platelets, forming a clot. Popular

29
Q

how does wound healing act as physical defence

A

The scabs formed by a dry blood clot shrinks as it dries out. This pulls the side of the cut together. Stem cells within the skin epidermis differentiate into new skin cells plus the associated blood vessels. Once healing is complete, the scab falls off.

30
Q

How does inflammation act as physical defence

A

If a microorganism can reach the skin’s defences. Must cells within the connective tissue release histamine? This has the effect of increasing the permeability of capillary walls to white blood cells. This in turn leads to increase production of tissue fluid causing oedema (swelling). Once the tissue fluid enters the lymphatic system. The invading pathogen is more likely to encounter lymphocytes.

31
Q

How does expulsive reflexes act as physical defence

A

Coughing, sneezing and vomiting. The presence of an irritant can induce any of these reflex responses. This may be due to the presence of a pathogen in which may have secreted a toxin. The purpose of these responses is to purge the body of harmful substances.

32
Q

physical defence in ear canal

A

Lines with wax which traps the pathogens

33
Q

what is phagocytosis

A

Phagocytes (type of white blood cell) travels in the blood and squeezes out of capillary to engulf & digest pathogens

34
Q

what are the 2 examples of phagocytes

A

Neutrophils
Macrophage

35
Q

explain the 7 step process of phagocytosis

A

Damaged cells & pathogens release cell-signalling chemicals (cytokines) which attract phagocytes at site of infection

An Opsonin protein can be attached to pathogen to allow the receptors on phagocytes to engulf the pathogens

Phagocytes then engulf pathogen into vesicle to create phagosome

Within phagocytes, there are lysosomes which contain hydrolytic lysosome enzyme

The lysosome fuses with phagosome to expose pathogen to lysosome.

The lysosome hydrolyses the pathogen

Macrophages become Antigen presenting cells by combining the antigens with glycoproteins in the cytoplasm called Major histocompatibility Complex (MHC). The MHC moves the antigens to their surface membrane which allows them to stimulate the other cells which are involved in the specific immune response

36
Q

what are the 2 types of lymphocytes & where are they made

A

B lymphocytes made & mature in Bone marrow

T Lymphocytes Made is bone marrow but mature in the Thymus Gland

37
Q

what is the function of T lymphocytes

A

T- Helper cells: Have CD4 receptors on their cell-surface membranes which bind to the surface antigens on APC. They produce interleukins, which are a type of cytokine (cell-signalling molecule). The interleukins made by T helper cells stimulate the activity of B cells, which increases antibody production and stimulates the production of other types of T cells and attracts and stimulates macrophages to ingest pathogens with antigen antibody complexes.

38
Q

What is the role of T killer cells

A

These destroy the pathogen carrying the antigen. They produce a chemical called perforin which kills the passage and by making holes in the cell membrane, so it is freely permeable.

39
Q

what is the role of T memory cells

A

These left for a long time and are part of the immunological memory. If they meet an antigen a second time, they divide rapidly to form a huge number of clones of T killer cells that destroy the pathogen.

40
Q

what is the role of T regulator cells

A

These cells suppress the immune system acting to control and regulate it. They stop the immune response once a passenger has been illuminated and make sure the body recognises self-antigens and does not set up an autoimmune response. Interleukins are important in this control.

41
Q

what is the role of plasma cells

A

These produce antibodies to a particular antigen and release them into the circulation. They only live for a few days but produces a lot of antibodies while it’s alive

42
Q

what is the role of B effector cells

A

These divides to form the plasma cell clones.

43
Q

what is the role of B memory cells

A

These live for a very long time and provide immunological memory. They are programmed to remember a specific antigen and enable the body to make a very rapid response when a passage and carrying their antigen is encountered again.

44
Q

explain the 3 step process of cell mediated response

A

1) An APC is created

2) The receptors on some T-Helper cells fit the antigen which become activated to release interleukins and stimulate more T cells to divide rapidly by mitosis. They form clones of identical activated T helper cells that all carry the right antigen to bind to a particular pathogen

3) The Cloned T cells may:

Develop into T memory cells which provide rapid response if this pathogen invades the body again

Produce interleukins that stimulate phagocytosis

Produce interleukins that stimulate B cells to divide

Stimulate the development of a clone of T killer cells that are specific for the presented and then destroy infected cell

45
Q

explain the 6 step process of humoral immunity

A

A B cell with complementary antibodies bind to antigen of pathogen to engulf it and process it to become APC

Activated T helper cells bind to B APC. The B cells with particular antigen is selected for cloning which is known as Clonal Selection.

Interleukins produced by act T helper cells active B cell

The activates B cell divides by mitosis to give clones of plasma cells & memory cells. This is known as clonal expansion

Cloned plasma cell produces antibodies that fit the antigen on the surface of the pathogen Condition. and bind to the antigens to disable them or act as opsonin’s or agglutinins. This is the primary response, and it takes days or even weeks to become fully effective against a particular pathogen.

Some cloned B cells develop into B memory cells. If the body is affected by the same passage, and again the B memory cells divide rapidly to form plasma cell clones. These produce the right antibody and wipe out the passage, and very quickly, before it can cause the symptom of disease. This is the secondary immune response.

46
Q

Structure of antibody

A

Antibodies are Y-shaped glycoproteins called immunoglobulins which bind to specific antigen on pathogen

Made of 2 long identical polypeptide chains (heavy chains) & 2 shorter identical chains (Light Chains) which are held together by disulphide bridges to keep shape

When antibody links to antigen it is called the antigen-antibody complex

The hinge region of antibody provides molecule with flexibility, allowing it to bind to 2 separate antigens at each of the antigen binding sites.

47
Q

explain how antibody works

A

The antigen-antibody complex acts as opsonin so the complex is easily engulfed & digested by phagocytes

Most pathogens can no longer effectively host cells once they are part of antigen-antibody complex

Antibodies act as agglutinins causing pathogens carrying antigen-antibody complexes to clump together. This helps prevent them spreading the body and makes it easier to engulf several pathogens at the same time

48
Q

what is active & natural immunity

A

Antibodies are actively produced by immune system in response to infection and later becomes immune to this disease e.g. chicken pox

49
Q

what is passive and natural immunity + explain 1 example

A

Antibodies passed from mother to baby via the placenta & breast milk

The baby can’t produce antibodies so relies on transfer from mother

The first milk of mammalian mother makes it Colostrum which is very high in antibodies and different in colour (more yellowish)

The infants gut allows glycoproteins to pass into bloodstream without digested allowing the baby to have the same level of antibody protection against disease as mother

50
Q

what is passive & artificial immunity

A

Antibodies injected into patient due to the body not making the antibodies fast enough leading to death e.g. hepatitis or snake bite antivenom

51
Q

what is active & artificial immunity

A

Immune system is stimulated to make its own antibodies to a safe form of antigen

This is done by injecting some form of antigen into bloodstream which is called a vaccine

52
Q

what form can antigen be in for a vaccine (5)

A

Killed or inactive

Attenuated (weakened)

Toxin molecules that have already been detoxified

Genetically engineered antigens

Isolated antigens

53
Q

what is epidemic

A

When a communicable disease spreads rapidly to a lot of people at a local or national level

54
Q

what is pandemic

A

Disease which spreads rapidly across number of countries & continents

55
Q

what is herd immunity

A

when significant number of people in population have been vaccinated which gives protection to those who haven’t been vaccinated as there is minimal opportunity for an outbreak to occur.

56
Q

what are 4 ways that a bacteria can build resistance

A

This could be due to mutation caused by bacterial reproduction to cause resistance to medication

This can also be caused when patients don’t finish their antibiotic course which allows the bacteria to become resistant

Resistant bacteria then reproduce to from more bacteria that is also resistant to the antibiotics

Overly using antibiotics

57
Q

2 examples of bacteria that built resistance and key info about them

A

MRSA effect skin & nose to produce boils. When treated with penicillin like antibiotic there was a mutation which made it resistant

C.difficile produces toxins that damage the lining of the intestine. Antibiotics were used but the bacteria survived, reproduced and become more serious

58
Q

6 ways to reduce antibiotic resistance

A

Stop overly using antibiotics

Finishing entire course of antibiotics on time

Changing the prescribed antibiotic so the same antibiotic isn’t prescribed for the same infection

Isolating infected patients

Practising good hygiene

59
Q

what is pharmacogenomics

A

investigates how persons genetic makeup can affect how body processes certain medications

60
Q

how cane we learn the impact of medicine on different genetics

A

Due to projects like the Human Genome Project, we can study genetics & thus understand which medications is best for everyone

61
Q

why are medication processes impacted by genetics

A

Due to difference in DNA sequence, the medications can have impact on the tertiary structure

62
Q

what is synthetic biology and why is it useful

A

Uses genetic engineering to develop populations of bacteria to produce much needed drugs that would be needed but are too rare, expensive or unavailable

This will also help us design more effective drugs that can treat bacteria faster

63
Q
A