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[OS 211] 2nd Lecture Exam > [4] Pharmacology of Anti-Epileptic Drugs > Flashcards

[4] Pharmacology of Anti-Epileptic Drugs Flashcards

1
Q

What type of receptor is GABA a?

A

Ligand gated

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2
Q

What type of receptor is GABA b?

A

GPCR

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3
Q

MoA of Muscimol

A

GABA A Agonist

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4
Q

MoA of Bicucilline

A

GABA A Antagonist

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5
Q

MoA of Picrotoxin

A

Blocks Chloride Channels

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6
Q

Antidote of Isoniazid Toxicity

A

Vitamin B (Pyridoxine)

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7
Q

This AED undergoes saturable kinetics

A

Phenytoin

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8
Q

Standard drug used for absence seizures in the Philippines

A

Valproate

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9
Q

MoA of Benzodiazepines

A

Enhances GABA induced increases in Cl conductance which hyperpolarizes the cell causing increased frequency of channel opening

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10
Q

This drug is used to reverse Benzodiazepine induced CNS Depression

A

Flumazenil

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11
Q

Pushing Diazepam too fast can cause?

A

Apnea

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12
Q

Fairly weak anti-epileptic drug requiring adjunct treatment

A

Gabpentin

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13
Q

What special property does Gabpentin have with regards to how it is excreted?

A

100% Renal Excretion

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14
Q

What special property does Gabpentin have with regards to how it is excreted?

A

100% Renal Excretion

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15
Q

MoA of Carbamazepine

A

Blocks sodium channels and inhibits generation of repetitive action potentials

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16
Q

Safest drug for women in child bearing age

A

Lamotrigine

17
Q

Safest drug for women in child bearing age

A

Lamotrigine

18
Q

MoA of Valproic Acid

A

Block sustained frequency by blocking sodium channels

Inhibits low threshold (T-type) Calcium channels

19
Q

Drug of choice for simple absence seizures

Drug of choice for compound absence seizures

A

Ethosuximide

Valproic Acid

20
Q

What % of Ethosuximide is protein bound?

A

0%

21
Q

What % of Ethosuximide is protein bound?

A

0%

22
Q

Effect on Carbamazepine by Phenobarbital

A

Decreased

23
Q

Effect on Carbamazepine by Phenytoin

A

Decreased

24
Q

Effect on Carbamazepine by Valproic Acid

A

Increased

25
Q

Most reactive AED drug

A

Phenytoin

26
Q

Usual reaction of Gabapentin to other AED drugs in adjunct therapy

A

No reaction

[OS 211] 2nd Lecture Exam (11 decks)

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