[4] Pharmacology of Anti-Epileptic Drugs Flashcards
(26 cards)
What type of receptor is GABA a?
Ligand gated
What type of receptor is GABA b?
GPCR
MoA of Muscimol
GABA A Agonist
MoA of Bicucilline
GABA A Antagonist
MoA of Picrotoxin
Blocks Chloride Channels
Antidote of Isoniazid Toxicity
Vitamin B (Pyridoxine)
This AED undergoes saturable kinetics
Phenytoin
Standard drug used for absence seizures in the Philippines
Valproate
MoA of Benzodiazepines
Enhances GABA induced increases in Cl conductance which hyperpolarizes the cell causing increased frequency of channel opening
This drug is used to reverse Benzodiazepine induced CNS Depression
Flumazenil
Pushing Diazepam too fast can cause?
Apnea
Fairly weak anti-epileptic drug requiring adjunct treatment
Gabpentin
What special property does Gabpentin have with regards to how it is excreted?
100% Renal Excretion
What special property does Gabpentin have with regards to how it is excreted?
100% Renal Excretion
MoA of Carbamazepine
Blocks sodium channels and inhibits generation of repetitive action potentials
Safest drug for women in child bearing age
Lamotrigine
Safest drug for women in child bearing age
Lamotrigine
MoA of Valproic Acid
Block sustained frequency by blocking sodium channels
Inhibits low threshold (T-type) Calcium channels
Drug of choice for simple absence seizures
Drug of choice for compound absence seizures
Ethosuximide
Valproic Acid
What % of Ethosuximide is protein bound?
0%
What % of Ethosuximide is protein bound?
0%
Effect on Carbamazepine by Phenobarbital
Decreased
Effect on Carbamazepine by Phenytoin
Decreased
Effect on Carbamazepine by Valproic Acid
Increased
