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PHAR 262 > 4 Part 2: Bone Agents > Flashcards

4 Part 2: Bone Agents Flashcards

1
Q

methylene diphosphonate akas

A

MDP or medronate

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2
Q

hydromethylene diphosphonate akas

A

HDP, HMDP, oxidronate
or TechneScan HDP

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3
Q

what do both the MDP and HDP have in their kits?

A

complexing agents, reducing agents, antioxidants, and inert atmosphere

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4
Q

how long is the incubation period for MDP? HDP?

A

MDP - 10 minutes
HDP - 30 seconds

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5
Q

MDP/HDP + Tc = (non/polar) RP

A

polar RP

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6
Q

what is the difference between MDP and HDP?

A

HDP has the extra OH- group

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7
Q

which pharm is tridentate and which is bidentate?

A

HDP - tri
MDP - bi

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8
Q

biodistribution of MDP/HDP

A

bone, kidneys/bladder

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9
Q

method of localization

A

chemisorption - binding to Ca2+ on bone crystals on bone surface

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10
Q

osteo(blast/clast) removes phosphonate compounds from the blood.

A

osteoblasts

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11
Q

higher degree of uptake in (HA/ACP) than in (HA/ACP)

A

higher degree of uptake in ACP than in HA

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12
Q

where do you see biodistribution of free pert?

A

thyroid, gastric mucosa, salivary glands, and choroid plexus

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13
Q

where do you see hydrolyzed reduced Tc/colloid formation?

A

liver

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14
Q

where do you see increased aluminum concentrations in eluate/plasma?

A

liver

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15
Q

long term steroid use

A

decreased bone uptake

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16
Q

cytotoxic therapy in breast cancer patients

A

diffuse calvaria uptake

17
Q

chemotherapy agents in kids

A

increased renal uptake

18
Q

effects of iron

A
  • focal increased soft tissue uptake at iron-dextran injection
  • decreased bone uptake with excessive plasma iron levels
  • spleen uptake in patients with sickle cell disease (increase iron levels)
19
Q

What is the name for altered biodistribution due to a drug or other medical treatment?

A

iatrogenic effects

20
Q

critical organ for HDP? MDP?

A

HDP - bone surface
MDP - bone surface or bladder wall (values are very close)

21
Q

use of MDP/HDP

A

assessing altered osteogenesis due to various pathologies

22
Q

dose of MDP/HDP

A

740-1110 MBq

PHAR 262 (12 decks)

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