4 Part 2: Bone Agents Flashcards
methylene diphosphonate akas
MDP or medronate
hydromethylene diphosphonate akas
HDP, HMDP, oxidronate
or TechneScan HDP
what do both the MDP and HDP have in their kits?
complexing agents, reducing agents, antioxidants, and inert atmosphere
how long is the incubation period for MDP? HDP?
MDP - 10 minutes
HDP - 30 seconds
MDP/HDP + Tc = (non/polar) RP
polar RP
what is the difference between MDP and HDP?
HDP has the extra OH- group
which pharm is tridentate and which is bidentate?
HDP - tri
MDP - bi
biodistribution of MDP/HDP
bone, kidneys/bladder
method of localization
chemisorption - binding to Ca2+ on bone crystals on bone surface
osteo(blast/clast) removes phosphonate compounds from the blood.
osteoblasts
higher degree of uptake in (HA/ACP) than in (HA/ACP)
higher degree of uptake in ACP than in HA
where do you see biodistribution of free pert?
thyroid, gastric mucosa, salivary glands, and choroid plexus
where do you see hydrolyzed reduced Tc/colloid formation?
liver
where do you see increased aluminum concentrations in eluate/plasma?
liver
long term steroid use
decreased bone uptake
cytotoxic therapy in breast cancer patients
diffuse calvaria uptake
chemotherapy agents in kids
increased renal uptake
effects of iron
- focal increased soft tissue uptake at iron-dextran injection
- decreased bone uptake with excessive plasma iron levels
- spleen uptake in patients with sickle cell disease (increase iron levels)
What is the name for altered biodistribution due to a drug or other medical treatment?
iatrogenic effects
critical organ for HDP? MDP?
HDP - bone surface
MDP - bone surface or bladder wall (values are very close)
use of MDP/HDP
assessing altered osteogenesis due to various pathologies
dose of MDP/HDP
740-1110 MBq
