Indium Labelling RP Flashcards
What is the unlabelled form of In?
InCl3
since unlabelled In-11 hydrolyzes easily, what is the ideal pH it needs to be stored in?
less than 3
Unlabelled In is used for clinical studies just like how unlabelled iodide can be used. T/F
false.
all labelled
why are bifunctional chelating agents used?
is an intermediary between RN and the pharm.
- for when the pharm doesn’t form a stable bond with the RN (low compatibility)
- when the complexing agent is a protein or antibody
In-111 is highly attracted to ___ in vivo.
plasma proteins
what In RP do techs label? manufacturers?
techs = octreotide
mans = DTPA and WBCs
describe In-111 octreotide.
it is a hormone analogue labelled using a bifunctional chelating agent
akas for octreotide
pentetreotide, octreoscan
labelling Octreotide, what is used as the bifunctional chelating agent?
DTPA!
where does octreotide localize?
tumors with somatostatin receptors (normally found in liver, spleen, kidneys, thyroid, pituitary)
method of localization for octreotide?
receptor binding
route of excretion for octreotide?
kidneys
(~50% by 6 hrs, 90% by 48 hrs)
critical organ for octreotide?
spleen
dose for Octreotide
111-222 MBq
what are some important precautions for octreotide?
- don’t inject the RP through TPN
- pts need to suspend octreotide therapies
- hydration is important
- bowel cleansing is recommended
- can cause hypoglycemias in pts with insulinoma thus glucose before administration is needed
