4- Mechanisms of Chronic Inflammation Flashcards
When does chronic inflammation occur?
24-27 hours after acute inflammation that is persistent
What is the important cell involved in chronic inflammation?
Macrophages (M1/M2 cells)
M2 cells convert arginine to what?
Orthinine
M1 cells convert arginine to what
nitric oxide
Orthinine is what in extracellular fluid & what is its role?
Proline in extra cellular fluid
Precursor for collagen synthesis
How do infectious granulomas differ to non infectious?
Caused by a pathogen not just foreign material
Describe the structure of a sterile granuloma
Necrotic centre- made up of foreign material
foreign material and neutrophils
Macrophages of different stages including giant cells
What are the 3 stages of tissue repair
Inflammation
Proliferation
Maturation
What is the difference between a sterile and infectious granuloma
Have a similar structure to sterile granuloma
Infectious granuloma will also include lymphocytes
Define pyogranulomatous
Chronic inflammatory lesion
A lot of macrophages & neutrophils
Large granuloma
Name a disease that pyogranulomatous lesions are seen in
Johnes disease
Feline infectious peritonitis
What is chronic granulomatous disease
Inherited disorder
Phagocytes don’t work properly.
Increased susceptibility to repeated bacterial or fungal infections.
What is chronic pyelonephritis
A chronic inflammation of the kidney or kidneys
Pyogenic granulomas
Kidneys swollen & stretched
Name 3 diseases/conditions that involve granulomas
Chronic pyelonephritis
Actinobacillosis (bacteria)
Chronic mastitis
TB
Immune-mediated arteritis
Chronic hepatitis
Lung pyogranuloma
Chronic interstitial nephritis
Healing bone
Describe the effect that nitric oxide has on organisms
Nitric oxide is Highly toxic to phagocytosed organisms
