4- Differential diagnoses for cutaneous/ subcutaneous masses

Question 1

Advantages of FNA/FNS

Answer 1

Quick,
simple
cheap
possible to do in house
Helpful in establishing a diagnosis

Question 2

List 2 types of Inflammation seen in a mass

Answer 2

Neutrophilic
Pyogranulomatous
Granulomatous (macrophages)
Eosinophilic

Question 3

Give an example of an epithelial skin tumour

Answer 3

Trichoblastoma
Trichoepithelioma
Squamous cell carcinoma
Anal sac apocrine adenocarcinoma
Perianal gland adenoma

Question 4

Where do mesenchymal tumours arise from?

Answer 4

Connective tissue, muscle, bone, cartilage, nerve, endothelial cells

Question 5

Which neoplastic cell type is embedded in a matrix & often has a cytoplasmic tails?

Answer 5

Mesenchymal

Question 6

What is a lipoma?

Answer 6

Benign tumour of adipose tissue

Adipocytes with small nucleus & abundant cytoplasm

Subcut fat looks identical

Question 7

Name a round cell tumour

Answer 7

Mast cell
Lymphoma
Plasmacytoma
Histocytic

Question 8

What cells are seen in a lymphoma?

Answer 8

Lymphocytes

Question 9

what type of tumour will have cells adhered together forming a brick like structure

Answer 9

epithelial skin tumour

Question 10

Describe what you will see when looking at a mesenchymal skin tumour

Answer 10

Cells will have entwined nature, cytoplasm streams off in a single direction, may appear individually or together, cell borders are hard to distinguish

Question 11

if cytology of mass shows cytoplasm of cells packed with purple granules what is it most likely to be

Answer 11

Mast cell tumour- which is a type of round cell tumour

Question 12

If cells look like fried eggs, are not cohesive but are touching slightly what type of mass is it likely to be

Answer 12

cutaneous histocytoma- round cell tumour