4. Effecotr mechanisms of Humoral immunity: Elimination of Extracellular microbes and toxins

Question 1

What may happen with out immunity?

no innate?

no adaptive?

Answer 1

Question 2

effector functions of Abs from what chain?

effector functions happen when?

Answer 2

Heavy chain constant region Fc of Ig molecules

Effector functions of Abs triggered ONLY after Ag binding

Question 3

Effector functions of Abs

Answer 3

Question 4

Answer 4

Question 5

Ab effector functions by Fc portion

types and function?

Answer 5

Question 6

isotype switching

change where?

Affinity maturation

causes what?

reason we do what type of treatment?

Answer 6

Question 7

IgG half life

Fetal Ab?

how does this happen?

Answer 7

Question 8

Neutralization of microbes and toxins.

(via Abs)

Answer 8

Question 9

How Abs block infection spreading?

Answer 9

Question 10

neutralization of toxins (Abs)

Virulence factors

Answer 10

Question 11

Ab- mediated opsonization and phagocytosis

Answer 11

Ab of the IgG isotype coat (opsonize) microbes and promote their phagocytosis by binding to Fc receptors on phagocytes

Question 12

Types of Fc receptors

Answer 12

Question 13

FcgammaRI in phagocytosis and activation of phagocytes

What isotypes most efficient?

at what point in immune response?

Answer 13

Question 14

FcgammaRIIb receptor

when does it start to work?

Answer 14

Question 15

FcR mediated Ab feedback?

Answer 15

Question 16

IgE-FcepsilonRI action?

how quick is response?

what kills?

Answer 16

Question 17

FcgammaRIII receptor

causes what?

when does it happen?

Answer 17

Question 18

The complement system

Consists of what?

Answer 18

Question 19

Complement

what type of immunity?

activated by what?

inhibited by?

Answer 19

Question 20

complement depends on generation of what?

different pathways activation?

Answer 20

Question 21

alternative pathway

draw or just go over

Answer 21

Question 22

Alternative pathway proteins

what protein would you measure to see if working?

different proteins and functions?

Answer 22

Question 23

Classical pathway

Most efficient activators of complement?

Specifics of the first step

Answer 23

Question 24

C1 binding to Fc of IgM and IgG

Answer 24

Question 25

Formation of C3 convertase

Answer 25

Question 26

C5 convertase formation (from C3 convertase)

Answer 26

Question 27

Proteins of the classical pathway

Answer 27

Question 28

The Lectin pathway

Answer 28

Question 29

Lectin Pathway proteins

Answer 29

Question 30

Proteins of the MAC

Answer 30

Question 31

CR1 complement receptor

Ligands?

function?

Answer 31

Question 32

degradation of C3b

Answer 32

Question 33

CR2 complement receptor

Ligands?

functions

Answer 33

Question 34

CR3/CR4 complement receptor

Ligands?

Functions?

Answer 34

Question 35

Complement regulators

Answer 35

Question 36

C1 INH, DAF, and MCP

Answer 36

Question 37

What will cleave C3b attached to cell surfaces?

Answer 37

Question 38

What inhibits formation of the MAC?

Answer 38

• CD59 (inhibits poly C9 assembly)
• plasma S protein (inhibit insertion of C3b-C7)

Question 39

complement functions?

Answer 39

also cell lyses

Question 40

Complement deficiencies

what is most common?

What isn’t usually associated with increased infections?

What cause pyogenic bacterial infections?

Neisseria bacteria?

Answer 40

Question 41

complement side effect?

Answer 41

Question 42

neonatal immunity?

what is their major defense?

Answer 42

several months after birth major defense against infection is passive immunity provided by materanl antibodies

Question 43

Neonatal immunity.

how does transfer happen?

what Abs?

Answer 43

Question 44

neonatal titers of Ab and immunity graph

Answer 44

Question 45

innate immune evasion by extracellular bacteria

Answer 45

Question 46

Evasion of humoral immunity by microbes

Answer 46