2. effector mechanisms of T cell mediated immunity: functions of T cells in host defense Flashcards
Differentiation of CD4+ Th cell
what determines phenotype?
what is the process called?
what is naive Th?
types of Th cells and their functions?
differentiation of Th 1, 2, and 17 overview
starting with pathogen recognition
What are four properties of T cell cytokines?
what is the first identified T cell cyotkine?
what does TGF-beta do?
development of Th1 cells
functions of Th1 cells
activation of macrophages by Th1 cells
What cytokines are released by activated macrophages?
development of Th2 cells
what do they release?
Functions of Th2
Th1/Th2 activation of macrophages
Role of Th1/Th2 balance
development of Th17 cells
functions of Th17
activation and differentiation of CD8+ T cells
Where does it occur?
activation of CTLs
what are the 2 signals?
activated CTLs contain what?
what do they secrete?
what transcriptional factor is involved in CTL differentiation?
Magic of Cross-presentation.
what is it?
How does it work?
which come first effector CD4+ T cells or CD8+ T cells
approximately what times do they peak?
Why do CD4+ effector T cells precede generation of CD8+ T cells?
what is APC licensing what does it help?
Help differentiate CD8+ cells
Role of CD4+ T cells in activation of CTLs
CTLs role in acute viral infection?
CTL-mediated cytotoxicity
Killing of target cells by CTLs
look at picture for part B
two major mechanisms of killing (CTLs)
Granzymes-mediated apoptosis
what is required for CTL cytotoxicity?
What is similar to C9 complement?
Fas-FasL- Mediated Apoptosis
