2. effector mechanisms of T cell mediated immunity: functions of T cells in host defense Flashcards by Ross Larson | Brainscape

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Differentiation of CD4+ Th cell

what determines phenotype?

what is the process called?

what is naive Th?

types of Th cells and their functions?

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differentiation of Th 1, 2, and 17 overview

starting with pathogen recognition

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What are four properties of T cell cytokines?

what is the first identified T cell cyotkine?

what does TGF-beta do?

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development of Th1 cells

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functions of Th1 cells

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activation of macrophages by Th1 cells

What cytokines are released by activated macrophages?

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development of Th2 cells

what do they release?

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Functions of Th2

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Th1/Th2 activation of macrophages

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Role of Th1/Th2 balance

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development of Th17 cells

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functions of Th17

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activation and differentiation of CD8+ T cells

Where does it occur?

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activation of CTLs

what are the 2 signals?

activated CTLs contain what?

what do they secrete?

what transcriptional factor is involved in CTL differentiation?

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Magic of Cross-presentation.

what is it?

How does it work?

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which come first effector CD4+ T cells or CD8+ T cells

approximately what times do they peak?

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Why do CD4+ effector T cells precede generation of CD8+ T cells?

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what is APC licensing what does it help?

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Help differentiate CD8+ cells

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Role of CD4+ T cells in activation of CTLs

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CTLs role in acute viral infection?

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CTL-mediated cytotoxicity

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Killing of target cells by CTLs

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look at picture for part B

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two major mechanisms of killing (CTLs)

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Granzymes-mediated apoptosis

what is required for CTL cytotoxicity?

What is similar to C9 complement?

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Fas-FasL- Mediated Apoptosis

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