1. T-Cell mediated immunity activation of T lymphocytes by cell associated antigens

Question 1

CD28:CTLA4

Answer 1

An inhibitory signal

Question 2

CD28:CD80/86

Answer 2

An activating signal

Question 3

Adhesion with APCs?

Answer 3

LFA1:ICAM1

Question 4

TCR recognizes?

Answer 4

Recognizes MHC-assoctiated peptide

Question 5

CD4 or CD8 are what?

Answer 5

Question 6

CD3 does what?

Answer 6

Question 7

ITAMs do what?

Answer 7

Question 8

ITIMs do what?

Answer 8

Question 9

ITIMs do what?

Answer 9

Question 10

What are Costimulatory molecules?

Answer 10

Question 11

What are adhesion molecules?

Answer 11

Question 12

Answer 12

B7-1 and B7-2 are now called cluster of differentiation

Question 13

Superantigen-induced activation of T cells?

What are superantigens?

What disease do they cause?

are they processed?

Where do they bind?

once bound what happens?

Answer 13

Question 14

Signal 2?

Answer 14

costimulation

Question 15

Costimulation in T cell activation?

How are DCs involved in this?

Answer 15

Unactivated vs activated

Question 16

unactivated DCs in costimulation?

Answer 16

Question 17

Activated DCs?

How are DCs activated?

what costimulators may they express?

What do activated DCs also produce?

Answer 17

Question 18

Costimulation by CD28?

what do they promote?

homologues to receptor action?

outcome of T cell activation influenced by what?

Answer 18

innate immunity controls the next response

Question 19

What do APCs express?

What do T cells express?

Answer 19

ligands

Receptors

Question 20

Answer 20

Question 21

CTLA 4

and

PD1

(Picture)

Answer 21

Question 22

CTLA4 checkpoint

Where is it in or on cell?

how does it regulate?

Answer 22

Question 23

PD1 checkpoint

Major role?

what upregulates it?

what induces the expression of the ligands?

PD1L does what?

PD1L induction by?

what happens with excessive induction?

Answer 23

Question 24

Question 25

Signal 3?

Answer 25

Differentiation

Question 26

Signal 3 causes?

Answer 26

changes in expression of transcriptional factors

Question 27

Signal 3 cascades

Answer 27

Question 28

Activation and differentiation of CD8+ occurs where? Do they stay in the LN?

Answer 28

Question 29

CTLs activation. What signals? what kills the other cells? what do activated CTLs secrete? What transcriptional factor is important? what does this transcriptional factor do?

Answer 29

Question 30

Initiation of TCR signalling Step by step.

Answer 30

Question 31

T-cell receptor signalling starting at phosphorylated LAT.

Answer 31

Question 32

Changes in protein expression after CD4+ T cell activation First change? time?

Answer 32

Question 33

Biologic actions of IL-2 and when it changes in expression on graph?

Answer 33

Question 34

Properties of IL-2 how does it stim survival, proliferation, and differentiation? what is it required for the survival of? what else can in stimulate the proliferation and differentiation of?

Answer 34

Question 35

What proteins are these and what do they do?

Answer 35

Question 36

Changes in CD69 after T cell activation?

Answer 36

Question 37

CD25 expression in activated T cells

Answer 37

Question 38

Expression of CD40L in activated T Cell

Answer 38

Question 39

Decline of T cell response What causes it? What else contributes to the normal contraction of immune response?

Answer 39

Question 40

Development of effector and memory T Cells how long do they last? what proportion are they of lymphocytes? where do they reside? What drives differentiation in CD4+ what promotes memory cells?

Answer 40

Question 41

Development of effector and memory T cells? What determines function and status among types of T cells? How does this differ for the cells? What is a difference between Memory T cells and effector cells in DNA? what does memory T cells come from?

Answer 41

Question 42

Properties of memory cells? what allows them to survive without Ag present? how long does it take naive and memory cells for full response to Ag? compare the difference in the number of memory T cells vs Naive T cells

Answer 42

Question 43

properties of memory cells do memory cells stay in LN? what are major inducers of anti-apoptotic proteins for memory cells?

Answer 43

Question 44

memory T cell frequency Three distinct phases? generated when? in adulthood? in older age?

Answer 44

Question 45

properties of memory cells Types of memory T-cells? what do these produce? where do they reside?

Answer 45

Question 46

migration of T lymphocytes in cell mediated immune reactions. what molecules help them into LNs? out? what helps them find sites of infections?

Answer 46

Question 47