#4/#7 Zaman - Lung 2 and 3 Chronic Obstructive, Restrictive Pulmonary Disease Flashcards
Chronic Obstructive, Restrictive Pulmonary Disease
Identify
Centrilobular Ephysema
Upper lung involvement
Strongly associated with smoking
INACTIVATION of a1AT
Identify
Panacinar Emphysea
Lower lobe involvement
alpha-1-antitrypsin DEICIENCY
Identify
Lymphocytic Bronchiolitis
Lymphocytes surrounding bronchiole
Identify
Follicular Bronchiolitis
Identify
Proliferative Bronchiolitis
Cellular debris, necrosis
NOT fibrosis
Identify
Constrictive bronchiolitis
Fibrosis around bronchiole
Restriction
Masson body
Identify
Bronchiectasis (ectasis - expanded)
Dilation and defective branching –> branches should get smaller
Parallel lines seen in xray
The following is seen in your patient. What do these chronic mucus plugs indicate?
Severe asthma
Charcot-Leyden - fragments from eosinophils
Curschman spiral - granule and epithelium
Identify
Honeycomb Lung
On xray - cystic spaces
Identify
Diffuse Alveolar Damage (DAD)
Hyaline Membrane Stage
seen in acute ARDS
Identify
Restrictive DAD
Identify
Usual Interstitial Pneumonia
Massan bodies
Biopsy: Fibrosis next to normal
No neutrophils or leukocytes
Worse outcome compared to NSIP
Identify
Non specific interstitial pneumonia (NSIP)
Uniform
Two sub patterns: Cellular and Fibrosing
better prognosis than UIP
Identify
Cryptogenic Organizing Pneumonia
Masson body
Typical Bronchial Alveolar Lavage (BAL)
Tx: Glucocorticoids and/or macrolides
Don’t confuse with sarcoid
Identify
End Stage Pulmonary Fibrosis
Honeycomb lung
Outcome appears no different between UIP and NSIP if disease is well advanced.
Identify
Sarcoid
Pulmonary fibrosis
Noncaseating granulomas
40% Lymphocyte (different from UIP)
Anergy and Hypergammaglobulinopathy
High risk: African Americans
Identify
Pulmonary Cyst
no bronchiole epithelium
Identify
Hamartoma
Coin Lesion
Disorganized pulmonary tissues: mostly bronchial epithelium and cartilage
Identify
Respiratory Distress Syndrome (newborn/premature)
Disorder from Type II lack of surfactant
Hyaline Membrane Disease
Identify
Goodpasture’s Syndrome
Hemmoptysis and Hematuria
Antibodies directed against a3 chain of Type IV collagen
Linear IgG
Identify
Wegener’s Granulomatosis
50s
Vasculitis involves:
Upper midline (nose, sinus, nasopharynx)
Lung
Kidney
Autoantibodies directed against c-ANCA
