3A, 3B Flashcards
Only part of an organism (binds)
ANTIGEN
Self- or Non-self
o Presence and absence in the host
ANTIGEN
Pathogenic or Non-pathogenic
o Exposure to pathogen = INFECTION
o ALLERGIC RX ≠ INFECTION
ANTIGEN
Primary function: To bind Ags
ANTIGEN
AB-generator [both binds (antigenic) to and forms (immunogenic) AB]
ANTIGEN
AG binds to AB
Antigenicity
causes AB formation
Immunogenicity
Antigenic determinants
o Foreign proteins
o Viruses, bacteria, parasites, fungi
Epitope
Responsible for doing the two basic properties of an AG .
Very small (4 to 5 polysaccharide units)
Epitope
An AB is created against this epitope but not to the entire microorganism
Paratope
Antibody determinants
Paratope
cause AB formation - substance
Immunogen
Carrier/ Schlepper Molecules
↓MW (IS doesn’t actually react)
Partial AG
Hapten
↑MW – AB production
Complete AG
Carrier/ Schlepper Molecules
o Can cause damage to the body due to ↑MW
Carrier/ Schlepper Molecules
Carbohydrate and lipids (nonprotein)
Hapten
Protein (most complex biomolecule – heavy)
Carrier/ Schlepper Molecules
With own epitopes
Carrier/ Schlepper Molecules
Ex.: Albumin, polypeptide, globulin
Carrier/ Schlepper Molecules
Ex.: Penicilin; Dinitrophenol
o Can bind to an available AB
Hapten
Glycoproteins
ANTIBODY or IMMUNOGLOBULI N (Ig)
Bind AGs; interacts with AG
ANTIBODY
– plasma cells
AB + WBC (surface)
o B cells
– coating during phagocytosis
o Opsonins
Phagocytosis site
o Liver and spleen
Entry of water =
EXPLOSION/LYSIS
Extravascular destruction of cells
Phagocytosis
Intravascular destruction of cells
EXPLOSION/LYSIS
Surface
Complement
Protein in nature ↑MW Immunogenic and antigenic
Carrier
Nonprotein in nature ↓MW Antigenic
Hapten