3.9 - Carboxylic Acids 2 Flashcards
Name of Mechanism: Reaction of Acyl Chlorides with Ammonia
Nucleophilic Addition-Elimination
Name of Mechanism: Hydrolysis of Acyl Chlorides
Nucleophilic Addition-Elimination
Name of Mechanism: Reaction of Acyl Chlorides with Ammonia
Nucleophilic Addition-Elimination
Name of Mechanism: Reaction of Acyl Chlorides to form Amides
Nucleophilic Addition-Elimination
What does a Double-headed curly arrow show?
The Movement of a Pair of Electrons
What is an Acyl group?
R-C=O
Define: Nucleophile
Electron Pair Donor
General Equation: Hydrolysis of Acyl Chlorides
R-C(=O)-Cl +H₂O |> R-C(=O)-OH + HCl
General Equation: Reaction of Acyl Chlorides with Alcohol
RCOCl + R’OH |> RCOOR’ + HCl
General Equation: Reaction of Acyl Chlorides to form Amides
RCOCl + 2R’NH₂ |> R-C(=O)-NH-R’ + R’NH₃⁺Cl⁻
General Equation: Hydrolysis of Acid Anhydrides
R-C(=O)-O-C(=O)-R + H₂O |> 2R-C(=O)-OH
General Equation: Reaction of Acyl Chlorides with Ammonia
RCOCl + 2NH₃ |> R-C(=O)-NH₂ + NH₄Cl
Reagent: Reaction of Acyl Chlorides to form Amides
R’NH₂
Reagent: Reaction of Acyl Chlorides with Ammonia
NH₃
Reagent: Hydrolysis of Acid Anhydrides
H₂O