36.monobactams

Question 1

what are monobactams

Answer 1

1- monocyclic and bacterially-produced β-lactam antibiotics.
2 - The β-lactam ring is not fused to another ring, in contrast to most other β-lactams

Question 2

name drugs that are monobactams

Answer 2

Aztreonam- flac sicc 1g

Question 3

PK of monobactams

Answer 3

• A- only given parenterally (IV or IM)
• M- not metabolised
  
  • Does NOT penetrate BBB or PB
• E- urine

Question 4

MoA of monobactams

Answer 4

1- inhibition of bacterial cell wall synthesis due to a high affinity of aztreonam for penicillin binding protein 3 (PBP3).
2- By binding to PBP3, aztreonam inhibits the third and last stage of bacterial cell wall synthesis.
3 - Cell lysis is then mediated by bacterial cell wall autolytic enzymes

Question 5

SoA of monobactams

Answer 5

1.gram -

Question 6

therapeutic uses of monobactams

Answer 6

1- antimicrobial activity directed primarily against gram-negative pathogens
2- Urinary tract infections
3- Lower respiratory tract infections
4- Septicemia
5- Skin and skin-structure infections
6- Intra-abdominal infections
7- Gynecologic infections

Question 7

contraindications for monobactams

Answer 7

1- Beta lactam allergies
2- Pregnancy
3- Renal impairment

Question 8

ADRs of monobactams

Answer 8

1- Nausea
2- Vomiting
3- Diarrhea
4- Abdominal pain
5- Skin rash
6- Abnormal taste in the mouth

Question 9

drug interactions of monobactams

Answer 9

1- Aztreonam may decrease the excretion rate of Abacavir which could result in a higher serum level
2- Acetaminophen may decrease the excretion rate of Aztreonam which could result in a higher serum level.
3- Acetylsalicylic acid may decrease the excretion rate of Aztreonam which could result in a higher serum level.