35.lincosamides

Question 1

Name drugs that belong to the group of Lincosamides

Answer 1

1.Lincomycin - caps.250mg
2. Clindamycin - caps.150mg and 300mg

Question 2

give a definition of Clindamycin

Answer 2

is a chlorine-substitued derivative of lincomycin,

Question 3

MoA of clindamycin

Answer 3

1.binds to 50S subunit - bacterioSTATIC
2. used in treatment against Gram +
-MRSA, streptococci, anaerobic bacteria

Question 4

which microorganism is always resistant to clindamycin

Answer 4

c.difficile

Question 5

administration of clindamycin

Answer 5

1.iv
2.oral

Question 6

distribution of clindamycin

Answer 6

1.well into all body fluids, including bone
2.poor entry into CSF
3.highly PBB

Question 7

metabolism of clindamycin

Answer 7

undergoes extensive oxidative metabolism to inactive products

Question 8

excretion of clindamycin

Answer 8

into the bile, low urinary elimination - poor for UTI

Question 9

ADRs of clindamycin

Answer 9

1.skin rashes
2.diarrhea - pseusomembranous colities due to C.difficile overgrowth - give metronidazole
3.hematotoxicity
4.hepatotoxicity

Question 10

SoA of lincosamides

Answer 10

broad (gram +)